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Fibrous Dysplasia

  • Piero PicciEmail author
Chapter
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Abstract

Definition: Intramedullary lesion consisting of a peculiar fibro-osseous tissue; it may be either monostotic or polyostotic.

Keywords

Epidemiology Imaging Histopathology Course and staging Treatment McCune–Albright syndrome Mazabraud syndrome 

Selected Bibliography

  1. Anitha N, Sankari SL, Malathi L, Karthick R. Fibrous dysplasia-recent concepts. J Pharm Bioallied Sci. 2015;7(Suppl 1):S171–2.PubMedPubMedCentralGoogle Scholar
  2. Case DB, Chapman CN Jr, Freeman JK, Polga JP. Best cases from the AFIP: atypical presentation of polyostotic fibrous dysplasia with myxoma (Mazabraud syndrome). Radiographics. 2010;30(3):827–32.CrossRefGoogle Scholar
  3. Dorfman HD. New knowledge of fibro-osseous lesions of bone. Int J Surg Pathol. 2010;18(3 Suppl):62S–5S. Review.CrossRefGoogle Scholar
  4. Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret AD, Louis-Brennetot C, Aurias A, Coindre JM, Guillou L, Pedeutour F, Duval H, Collin C, de Pinieux G. MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. Mod Pathol. 2011;24:624–37.CrossRefGoogle Scholar
  5. Dumitrescu CE, Collins MT. McCune-Albright syndrome. Orphanet J Rare Dis. 2008;3:12.CrossRefGoogle Scholar
  6. Riddle ND, Bui MM. Fibrous dysplasia. Arch Pathol Lab Med. 2013;137(1):134–8.CrossRefGoogle Scholar
  7. Ruggieri P, Sim FH, Bond JR, Unni KK. Malignancies in fibrous dysplasia. Cancer. 1994;73(5):1411–24.CrossRefGoogle Scholar
  8. Szuhai K, Cleton-Jansen AM, Hogendoorn PC, Bovée JV. Molecular pathology and its diagnostic use in bone tumors. Cancer Genet. 2012;205(5):193–204.CrossRefGoogle Scholar
  9. Yoshida A, Ushiku T, Motoi T, Shibata T, Beppu Y, Fukayama M, Tsuda H. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod Pathol. 2010;23(9):1279–88.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Laboratory of Experimental OncologyIRCCS Istituto Ortopedico RizzoliBolognaItaly
  2. 2.I.S.G. Italian Sarcoma GroupBolognaItaly

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