Langerhans’ Cell Histiocytosis

  • Laura CampanacciEmail author


Definition: Group of multiple-systemic diseases may involve bone marrow, internal organs, skin, and mucosae, characterized by a histiocytic proliferation of granuloma-like aspect. The pathogenesis is unclear; viruses, bacteria, and genetic factors have been implicated. An immunological dysfunction has also been reported; familial occurrence is very rare.


Epidemiology Imaging Histopathology Course and staging Treatment 

Selected Bibliography

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Orthopedic Oncology DepartmentIRCCS Istituto Ortopedico RizzoliBolognaItaly

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