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Langerhans’ Cell Histiocytosis

  • Laura CampanacciEmail author
Chapter
  • 245 Downloads

Abstract

Definition: Group of multiple-systemic diseases may involve bone marrow, internal organs, skin, and mucosae, characterized by a histiocytic proliferation of granuloma-like aspect. The pathogenesis is unclear; viruses, bacteria, and genetic factors have been implicated. An immunological dysfunction has also been reported; familial occurrence is very rare.

Keywords

Epidemiology Imaging Histopathology Course and staging Treatment 

Selected Bibliography

  1. DiCaprio MR, Roberts TT. Diagnosis and management of Langerhans cell histiocytosis. J Am Acad Orthop Surg. 2014;22(10):643–52.CrossRefGoogle Scholar
  2. Ghanem I, Tolo VT, D’Ambra P, Malogalowkin MH. Langerhans cell histiocytosis of bone in children and adolescents. J Pediatr Orthop. 2003;23(1):124–30.PubMedGoogle Scholar
  3. Han I, Suh ES, Lee SH, Cho HS, Oh JH, Kim HS. Management of eosinophilic granuloma occurring in the appendicular skeleton in children. Clin Orthop Surg. 2009;1(2):63–7.CrossRefGoogle Scholar
  4. Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer. 1999;85(10):2278–90.CrossRefGoogle Scholar
  5. Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK. Langerhans’ cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer. 1995;76(12):2471–84.CrossRefGoogle Scholar
  6. Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA. Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br. 2002;84(6):870–2.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Orthopedic Oncology DepartmentIRCCS Istituto Ortopedico RizzoliBolognaItaly

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