Role of Chemokines and Chemokine Receptors in Infectious Diseases and Targeting Strategies

  • Heena V. Maithania
  • Anisha A. D’Souza
  • Prajakta Dandekar
  • Padma V. DevarajanEmail author
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)


Chemokine receptors, a family of G-protein-coupled receptors (GPCRs), bind in a specific manner to chemokines and elicit cellular responses. Their involvement in inflammatory diseases is predominant. Although the main function of chemokine receptors is enrolment of leukocytes at the site of inflammation, they are also widely explored as drug discovery targets. This is due to the fact that blockage of chemokine receptor may provide novel therapeutic interventions. This chapter discusses the various chemokine receptors, involvement of chemokine receptors in the pathogenesis of various diseases, and receptor-mediated strategies to tackle such afflictions.


Chemokines G protein-coupled receptor Receptor-mediated targeting Signaling Ligands Cytokines Transmembrane 



Atypical chemokine receptor


Acquired immune deficiency syndrome




Burkitt’s lymphoma receptor 1


Cyclic adenosine monophosphate


Cluster of differentiation 4


Chinese hamster ovary


Cerebral malaria


Central nervous system


Chronic obstructive pulmonary disease




Duffy antigen receptor for chemokines


Epstein–Barr virus


EBI1 ligand chemokine


Granulocyte chemotactic Protein


Guanosine diphosphate


G-protein-coupled receptors


Guanosine triphosphate


Graft versus host disease


Human cytomegalovirus


Human immunodeficiency virus


HIV encephalitis


Herpes simplex virus


Inflammatory bowel disease

IC 50

inhibitory concentration 50






interferon-inducible T-cell alpha chemoattractant




Monocyte chemotactic/chemoattractant protein


monokine induced by gamma interferon


Macrophage inflammatory protein


Messenger ribonucleic acid


Medullary thyroid carcinomas


Neutrophil-activating peptide


Natural killer


Phosphatidylinositol 4, 5-biphosphate


Phospholipase C


Polylactic-co-glycolic acid


Placental malaria


Papillary thyroid carcinomas


Rheumatoid arthritis


Regulated on activation normal T-cell expressed and secreted


Relapsing–remitting multiple sclerosis


Stromal-derived Factor




Secondary lymphoid tissue chemokine


Thymus-expressed chemokine


T lymphocytes


Threonine x proline


West Nile virus


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Heena V. Maithania
    • 1
  • Anisha A. D’Souza
    • 2
  • Prajakta Dandekar
    • 3
  • Padma V. Devarajan
    • 3
    Email author
  1. 1.Department of Pharmaceutical Sciences &TechnologyInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Piramal Enterprises Limited, Pharmaceutical R&DMumbaiIndia
  3. 3.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia

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