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Mannose Receptor and Targeting Strategies

  • Priyanka Jahagirdar
  • Amit S. Lokhande
  • Prajakta Dandekar
  • Padma V. DevarajanEmail author
Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)

Abstract

The mannose family receptors are unique multidomain, multifunctional endocytic receptors belonging to the C-type lectin family. These receptors, although structurally similar, exhibit differential binding to discrete ligands. This chapter discusses such similarities and differences between the structures, ligands, the expression, and molecular trafficking among the members of mannose receptor family. Further, targeted drug delivery strategies in infections and cancer to the most widely investigated receptor of the family, the mannose receptor, are comprehensively explained with examples.

Keywords

Mannose receptor family Mannose conjugates Nanoparticles Liposomes Vaccines Infections Cancer 

Abbreviations

CD

Cluster of differentiation

CTLD

C-type lectin domain

DCs

Dendritic cells

DRV

Dehydration–rehydration vesicle

HIV

Human Immunodeficiency Virus

IFN

Interferon

IL

Interleukin

LAM

Lipoarabinomannan

LPS

Lipopolysaccharide

MMP

Matrix metalloproteinases

MRI

Magnetic resonance imaging

NPs

Nanoparticles

PEG

Polyethylene glycol

PLA2

Phospholipase A2

PLGA

Poly (lactide-co-glycolide)

RES

Reticuloendothelial system

SLA

Soluble leishmanial antigen

SPIONs

Superparamagnetic iron oxide nanoparticles

TAM

Tumor-associated macrophages

TB

Tuberculosis

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Priyanka Jahagirdar
    • 1
  • Amit S. Lokhande
    • 1
  • Prajakta Dandekar
    • 2
  • Padma V. Devarajan
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences & TechnologyInstitute of Chemical TechnologyMatunga, MumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia

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