Scavenger Receptor and Targeting Strategies

  • Amit S. Lokhande
  • Priyanka Jahagirdar
  • Prajakta Dandekar
  • Padma V. DevarajanEmail author
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 39)


Scavenger receptors constitute a group of receptors on the cell surface that attach to various ligands and remove the targets that are non-self or altered. Signaling, transport, endocytosis, phagocytosis, and adhesion resulting in the removal of harmful and degraded substances are some functions of these receptors. Scavenger receptors bind a large repertoire of ligands indicating their involvement in homeostasis and multiple disease pathologies. In this chapter, we describe the role of scavenger receptor group in the pathogenesis of infections and cancer. In addition, we present a variety of ligands with their scavenger receptor binding strategies through different examples of targeted drug delivery systems.


Cancer Infections Nanosystems Polyanionic ligand Scavenger receptor Targeted drug delivery 



Acylated low-density lipoprotein


Polyaconitylated-human serum albumin


Advanced glycation end products


Silver nanoparticles


Blood–brain barrier


Bovine serum albumin


Colony-forming units


Cysteine rich


Chemokine receptor 16




Dendritic cells


Endothelial cells


Epidermal growth factor


Iron oxide


Fasciclin EGF-like, and lamin-type EGF-like domains




High-density lipoprotein


Heat shock proteins


Lysosome-associated membrane glycoprotein


Lithocholic oleate


Low-density lipoprotein


Low-density lipoprotein receptor


Lectin-like oxidized LDL receptor-1




Lipoteichoic acid


Macrophage receptor with collagenous structure


Maleylated albumin





NK cells

Natural Killer cells


Oxidized low-density lipoprotein


p-amino salicylic acid










Red blood cells


Reactive oxygen species


Stabilin-1 interacting chitinase-like protein


Scavenger receptor class A member 5


Small interfering ribonucleic acid


Single nucleotide polymorphism


Secreted protein acidic and rich in cysteine


Scavenger receptor


Scavenger receptors with C-type lectin


Scavenger receptor that binds phosphatidylserine and oxidized lipids


Tumor-associated macrophages


Titanium dioxide


Uteroglobin-related protein


Very low-density lipoproteins


Zinc oxide


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Amit S. Lokhande
    • 1
  • Priyanka Jahagirdar
    • 1
  • Prajakta Dandekar
    • 2
  • Padma V. Devarajan
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences & TechnologyInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Department of Pharmaceutical SciencesInsitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of MaharashtraMumbaiIndia

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