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Drug-Resistant Tuberculosis and HIV

  • Sara C. Auld
  • Neel R. Gandhi
  • James C. M. Brust
Chapter

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB are associated with substantially worse outcomes than drug-susceptible TB—especially in the setting of HIV co-infection. Although global TB incidence has decreased over the past decade, drug-resistant TB remains a substantial threat to control of TB worldwide. This chapter reviews the epidemiology of drug-resistant TB, common genetic mutations conferring resistance to first and second-line TB drugs, as well as current diagnostic methods and principles of treatment. Therapy for drug-resistant TB is complicated, associated with frequent side effects, and a field of active research. Several new and repurposed drugs, such as bedaquiline and delamanid, have recently come to market or are in active clinical development. Guidelines change frequently and consultation with a clinician who has expertise in the co-management of drug-resistant TB and HIV is recommended.

Keywords

Multidrug-resistant Extensively drug-resistant MDR TB XDR TB Mono-resistance 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sara C. Auld
    • 1
  • Neel R. Gandhi
    • 2
  • James C. M. Brust
    • 3
  1. 1.School of Medicine and Rollins School of Public HealthEmory UniversityAtlantaUSA
  2. 2.Rollins School of Public Health and School of MedicineEmory UniversityAtlantaUSA
  3. 3.Albert Einstein College of MedicineMontefiore Medical CenterBronxUSA

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