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Acute Respiratory Distress Syndrome

  • Zachary D. Levy
  • Todd L. Slesinger
  • Brian J. Wright
Chapter
  • 64 Downloads

Abstract

In 1967, Ashbaugh, et al. published a case series of 12 patients in The Lancet where they described a respiratory malady characterized by tachypnea, hypoxemia, and a loss of lung compliance, brought on by a variety of different stimuli. They noted that the condition bore a resemblance to “congestive atelectasis” and that the most effective therapy was positive end-expiratory pressure (PEEP) (Ashbaugh DG, Bigelow DB, Petty TL, Levine BE, Lancet 2:319–23, 1967). Today, we readily identify the condition as acute respiratory distress syndrome (ARDS), at times known as “adult respiratory distress syndrome,” “shock lung,” “wet lung,” or “Da-Nang lung” (owing to the large volume of cases treated at the port city during the Vietnam War). What was once a dim recognition of heterogeneously triggered clinical symptoms is now a comprehensive and continuously evolving understanding of a discrete syndrome. Here, we will briefly describe the epidemiology of ARDS, explore the pathophysiology of ARDS-related lung injury, identify precipitating factors, and discuss current and future treatment approaches.

Keywords

Respiratory Distress ARDS Critical care Tidal volumes Distress syndrome 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Zachary D. Levy
    • 1
  • Todd L. Slesinger
    • 2
  • Brian J. Wright
    • 3
  1. 1.Emergency Medicine and NeurosurgeryZucker School of Medicine at Hofstra/NorthwellHempsteadUSA
  2. 2.Herbert Wertheim College of MedicineFlorida International University, MiamiFLUSA
  3. 3.Emergency Medicine and Neurosurgery Stony Brook University School of MedicineStony BrookUSA

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