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Endometrial Gene Expression for HHV-6

  • Carolyn Coulam
Chapter

Abstract

Viral infections have been considered as possible environmental factors in human infertility. Two studies have confirmed the association of HHV-6 expression of endometrial cells and infertility providing a compelling suggestion of a role of HHV-6 in the etiology of infertility. This chapter describes HHV-6, discusses the association of HHV-6 and infertility, and reviews methods of detection of HHV-6 expression within the uterus.

Keywords

Human herpesvirus 6 Infertility Uterine expression of HHV-6 

References

  1. 1.
    Milne SA, Critchley HO, Drudy TA, Kelly RW, Baird DT. Perivascular interleukin-8 messenger ribonucleic acid expression in human endometrium varies across the menstrual cycle and in early pregnancy decidua. J Clin Endocrinol Metab. 1999;84:2563–7.PubMedGoogle Scholar
  2. 2.
    Seli MD, Senturk LM, Bahtiyar OM, Kayisli UA, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertil Steril. 2001;75:1172–6.CrossRefGoogle Scholar
  3. 3.
    Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50–60.CrossRefGoogle Scholar
  4. 4.
    Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology. 2006;147:1097–121.CrossRefGoogle Scholar
  5. 5.
    Timeva T, Shterev A, Kyurkchiev S. Recurrent implantation failure: the role of the endometrium. J Repro Infertil. 2014;15:173–83.Google Scholar
  6. 6.
    Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril. 2004;82:799–804.CrossRefGoogle Scholar
  7. 7.
    Rhoads DD, Cox SB, Rees EJ, Sun Y, Wolcott RD. clinical identification of bacteria in human chronic wound infections: culturing vs. 16S ribosomal DNA sequencing. BMC Infect Dis. 2012;12:321–6.CrossRefGoogle Scholar
  8. 8.
    Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod. 2015;30:323–30.CrossRefGoogle Scholar
  9. 9.
    Marci R, Gentili V, Bortolotti D, Lo Monte G, Caselli E, Bolzan S, et al. Presence of HHV-6A in endometrial epithelial cells from women with primary unexplained infertility. PLoS One. 2016;11:e0158304.CrossRefGoogle Scholar
  10. 10.
    Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, et al. Prevalence of HHV-6 in endometrium from women with recurrent implantation failure. Am J Reprod Immunol. 2018;80:e12862.CrossRefGoogle Scholar
  11. 11.
    Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988;1:1065–7.CrossRefGoogle Scholar
  12. 12.
    De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005;18:217–45.CrossRefGoogle Scholar
  13. 13.
    Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P. CD46 is a cellular receptor for human herpesvirus 6. Cell. 1999;99:817–27.CrossRefGoogle Scholar
  14. 14.
    Cook SD, Paveloff MJ, Doucet JJ, Cottingham AJ, Sedarati F, Hill JM. Ocular herpes simplex virus reactivation in mice latently infected with latency-associated transcript mutants. Investig Ophthalmol. 1991;32:1558–61.Google Scholar
  15. 15.
    Baecher-Lind LE, Miller W, Wilcox AJ. Infectious disease and reproductive health: a review. Obstet Gynecol Surv. 2010;65:53–65.CrossRefGoogle Scholar
  16. 16.
    Naumenko V, Tyulenev Y, Kurilo L, Shileiko L, Sorokina T, Evdokimov V, et al. Detection and quantification of human herpes viruses types 4–6 in sperm samples of patients with fertility disorders and chronic inflammatory urogenital tract diseases. Androl. 2014;2:687–94.CrossRefGoogle Scholar
  17. 17.
    Wang H, Chen M, Berneman ZN, Delgado G, DiPaolo JA. Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction. J Virol Methods. 1994;47:297–305.CrossRefGoogle Scholar
  18. 18.
    Ohashi M, Yoshikawa T, Ihira M, Suzuki K, Suga S, Tada S, et al. Reactivation of human herpesvirus 6 and 7 in pregnant women. J Med Virol. 2002;67:354–8.CrossRefGoogle Scholar
  19. 19.
    Okuno T, Oishi H, Hayashi K, Nonogaki M, Tanaka K, Yamanishi K. Human herpesviruses 6 and 7 in cervixes of pregnant women. J Clin Microbiol. 1995;33:1968–70.PubMedPubMedCentralGoogle Scholar
  20. 20.
    Baillargeon J, Piper J, Leach CT. Epidemiology of human herpesvirus 6 (HHV-6) infection in pregnant and nonpregnant women. J Clin Virol. 2002;16:149–57.CrossRefGoogle Scholar
  21. 21.
    Maeda T, Okuno T, Hayashi K, Nagata M, Ueda M, Terashima K, et al. Outcomes of infants whose mothers are positive for human herpesvirus-6 DNA within the genital tract in early gestation. Acta Paediatr Jpn. 1997;39:653–7.CrossRefGoogle Scholar
  22. 22.
    Leach CT, Newton ER, McParlin S, Jenson HB. Human herpesvirus 6 infection of the female genital tract. J Infect Dis. 1994;169:1281–3.CrossRefGoogle Scholar
  23. 23.
    Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, et al. Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J Clin Microbiol. 1991;29:367–72.PubMedPubMedCentralGoogle Scholar
  24. 24.
    Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, et al. CD134 is a cellular receptor specific for human herpesvirus-6B entry. Proc Natl Acad Sci U S A. 2013;110:9096–9.CrossRefGoogle Scholar
  25. 25.
    Rizzo R, DiLuca D. Endometrium infection by human herpes virus 6A: implication in female idiopathic infertility. Fertil Steril. 2018;110:e128.CrossRefGoogle Scholar
  26. 26.
    Miguel RDV, Sheridan BS, Harvey SAK, Schreiner RS, Hendricks RL, Cherpes TL. 17-β estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent. J Virol. 2010;84:565–72.CrossRefGoogle Scholar
  27. 27.
    Caselli E, Zatelli M, Rizzo R, Benedetti S, Martorelli D, Trasforini G, et al. Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto’s thyroiditis. PLoS Pathog. 2012;8:e1002951.CrossRefGoogle Scholar
  28. 28.
    Davies ML, Dambaeva SV, Katukurundage D, Repak M, Gilman-Sachs A, Kwak-Kim J, Beaman KD. Predicting NK cell subsets using gene expression levels in peripheral blood and endometrial biopsy specimens. Am J Reprod Immunol. 2017;78:e12730.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Carolyn Coulam
    • 1
  1. 1.Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and ScienceNorth ChicagoUSA

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