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MicroRNA and Endometriosis

  • Swati Agrawal
  • Christian M. BeckerEmail author
Chapter

Abstract

Endometriosis is one of the most common benign gynecological disorders characterized by the presence of endometrial glands and stroma in extrauterine locations. It is associated with severe pain and infertility, and it has an enormous medical and economic burden on the society mainly due to the lack of a noninvasive test delaying its diagnosis. The recent discovery of microRNAs (miRNAs) as modulators of gene expression and their stability and specificity make them an attractive candidate as a biomarker. Tissue and circulating miRNAs have been proved to be helpful in the early diagnosis of various diseases. They have also been widely studied in endometriosis and are found to be responsible for the gene expression implicated in the development of the disease. Although the condition is multifactorial with complex pathogenesis, no specific miRNA or a group of them could be proven to be a useful biomarker. Also, the levels of miRNAs are influenced by multiple factors including ethnicity, age, body site, phase of the menstrual cycle, and the methods of detection. Moreover, there are a lot of challenges associated with isolating miRNAs and their levels. These factors account for the lack of concordance between the various studies. Many potential miRNAs have been found, and few of them are consistently dysregulated in most of the studies. Here, we will be elaborating on miR-200 family which plays an essential role in the pathogenesis of endometriosis. Discovery of a reliable biomarker will bring us a step closer to diagnosing endometriosis noninvasively and eliminating the lag phase.

Keywords

Endometriosis Endometrioma MicroRNA Biomarker Gene regulation 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyUniversity of TorontoTorontoCanada
  2. 2.Endometriosis CaRe Center, Nuffield Department of Women’s and Reproductive HealthUniversity of OxfordOxfordUK

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