Neurofibroma of Bone



Neurofibroma (NF) is a benign neoplasm originating in nerve fascicles and containing Schwann cells, fibroblasts, mast cells, axons, and variable collagen matrix. It is exceedingly rare in bone. NF originates in peripheral nerves at the periosteum, cortex, or vascular marrow. Most cases occur in the head and neck, especially the maxilla. Radiologically, neurofibroma is a radiolucent, well-circumscribed lesion. Relationship to known nerve tracts may suggest the diagnosis. Microscopically, the tumor is not well circumscribed, and its short spindle cells have long, wavy nuclei, with partial positivity for S100. Allelic loss of the NF1 gene region of 17q in Schwann cells is found. Wide resection is recommended to avoid recurrence.


Neurofibroma Neurofibromatosis Peripheral nerve Tumor Bone NF1 

Suggested Reading

  1. Fawcett KJ, Dahlin DC. Neurilemmoma of bone. Am J Clin Pathol. 1967;47:759–66.CrossRefGoogle Scholar
  2. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO classification of tumors of soft tissue and bone. Lyon: IARC; 2013. p. 174–6.Google Scholar
  3. Huang GS, Lee CH, Lee HS, Chang WC, Juan CJ, Chen CY. Solitary intraosseous neurofibroma of the tibia. Skelet Radiol. 2005;34:303–6.CrossRefGoogle Scholar
  4. Pontes HA, Pontes FS, Cruz e Silva BT, Fonseca FP, Carneiro JT Jr, Paiva HB, Pinto Ddos S Jr. Solitary neurofibroma of the temporal bone. J Craniofac Surg. 2010;21:1984–7.CrossRefGoogle Scholar
  5. Unni KK, Inwards C. Dahlin’s bone tumors. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010. p. 295.Google Scholar
  6. Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y. Solitary intraosseous neurofibroma of the frontal bone. Case report. Neurol Med Chir (Tokyo). 2010;50:683–6.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of PathologyA. C. Camargo Cancer CenterSão PauloBrazil

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