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Angiosarcoma is a high-grade malignant neoplasia characterized by cells with endothelial phenotype. Primary angiosarcoma of bone is rare and accounts for little more than 1% of primary bone sarcomas. Affected individuals have a broad age range; most are in the seventh decade of life, and males are affected slightly more frequently than females. Clinically, it usually presents as a painful, enlarging mass, which may cause pathologic fracture. Angiosarcoma has a wide skeletal distribution, with most lesions originating in the long bones and pelvis. Approximately 30% of tumors are multifocal. The neoplastic cells express endothelial markers; its epithelioid variant also stains with epithelial markers. Angiosarcoma is a very aggressive neoplasm, and the prognosis is dismal in most cases.
KeywordsAngiosarcoma Bone Malignant vascular tumor
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