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High-Grade Surface Osteosarcoma

  • Carrie Y. InwardsEmail author
  • Doris E. Wenger
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Abstract

High-grade surface osteosarcoma is a high-grade bone-forming neoplasm which arises on the surface of the bone. It has a male predominance. Peak incidence is in the second decade of life. A majority of patients are in the second and third decades of life. Radiologically, the lesion presents a large mass with a broad-based attachment to the underlying bone. There is a dense to moderate mineralization with a fluffy immature appearance. There is partial cortical destruction and periosteal new bone. Histologically, it is identical to conventional osteosarcoma (osteoblastic, chondroblastic, fibroblastic subtypes). All tumors are high grade. Treatment consists of neoadjuvant chemotherapy followed by surgical resection with a wide margin.

Keywords

Malignant bone-forming tumor Surface tumor Periosteal osteosarcoma Parosteal osteosarcoma 

Suggested Reading

  1. Okada K, Unni KK, Swee RG, Sim FH. High-grade surface osteosarcoma: a clinicopathologic study of 46 cases. Cancer. 1999;85(5):1044–54.CrossRefGoogle Scholar
  2. Staals EL, Bacchini P, Bertoni F. High-grade surface osteosarcoma: a review of 25 cases from the Rizzoli Institute. Cancer. 2008;112(7):1592–9.CrossRefGoogle Scholar
  3. Vanel D, Picci P, De Paolis M, Mercuri M. Radiological study of 12 high-grade surface osteosarcomas. Skelet Radiol. 2001;30(12):667–71. Epub 2001 Aug 30CrossRefGoogle Scholar
  4. Wold LE, Unni KK, Beabout JW, Pritchard DJ. High-grade surface osteosarcomas. Am J Surg Pathol. 1984;8(3):181–6.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  2. 2.Department of RadiologyMayo ClinicRochesterUSA

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