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Dynamic Control of Microvessel Diameters by Metabolic Factors

  • Axel R. PriesEmail author
  • Bettina Reglin
Chapter

Abstract

To maintain tissue function under steady state conditions and under increased workload, an adequate regulation of microvascular diameters is required. Microvessels continuously adapt to hemodynamic and metabolic stimuli. Vascular diameter increase in response to flow-induced shear stress establishes a positive feedback loop causing diameters of low-flow vessels to further decrease. This is balanced by metabolic signals released from vessels, tissue or red blood cells which can increase vascular diameters in undersupplied regions thus providing negative feedback regulation. Perturbation of these mechanisms leads to vascular maladaptation and microvascular dysfunction which underlies a multitude of clinical conditions possibly including myocardial angina in the absence of epicardial stenosis.

Keywords

Vascular adaptation Maladaptation Conduction Shear stress Microvascular dysfunction Metabolic signals Feedback 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of PhysiologyCharité Universitätsmedizin BerlinBerlinGermany
  2. 2.Deutsches Herzzentrum BerlinBerlinGermany

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