Technological Advancements to Promote Adherence
Non-adherence to prescribed medications costs the United States $100–$290 billion USD annually. There has been significant research and innovation surrounding the use of various health information technologies to improve adherence. Dermatology is a specialty with high rates of non-adherence. In this chapter, we present and discuss some of the technological advancements in medication adherence that can be utilized in dermatology. We outline various clinical interventional studies within the realms of mobile phone-based technology (text message reminders, telecommunications, smartphone applications), electronic health (web-based education, internet-based surveys, teledermatology), physical technologies/devices, and multimodal approaches. Furthermore, we describe emerging concepts within this domain along with highlighting technologies not yet studied in randomized controlled settings. In this fashion, this chapter is intended to inform the clinician about technological advancements to promote adherence and stimulate discussion of this important matter.
KeywordsAdherence Compliance Technology Mobile health Smartphone E-health Monitoring Interventions Dermatology
Conflicts of Interest
Mr. Vignesh Ramachandran, Dr. Abigail Cline, and Dr. Hawkins have no conflicts of interest to disclose.
- 3.Nieuwlaat R, Wilczynski N, Navarro T, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014;(11) https://doi.org/10.1002/14651858.CD000011.pub4.
- 24.Hawkins SD, Barilla S, Feldman SR. Web app based patient education in psoriasis – a randomized controlled trial. Dermatol Online J. 2017;23(4). http://www.ncbi.nlm.nih.gov/pubmed/28541882. Accessed March 29, 2019.
- 26.Tuong W, Armstrong AW. Participant satisfaction with appearance-based versus health-based educational videos promoting sunscreen use: a randomized controlled trial. Dermatol Online J. 2015;21(2). http://www.ncbi.nlm.nih.gov/pubmed/25756492. Accessed March 29, 2019.
- 28.Tuong W, Wang AS, Armstrong AW. Effect of automated online counseling on clinical outcomes and quality of life among adolescents with acne vulgaris: a randomized clinical trial. JAMA Dermatol. 2015;151(9):970–5. https://doi.org/10.1001/jamadermatol.2015.0859.CrossRefPubMedPubMedCentralGoogle Scholar
- 30.Causa Research. https://www.causaresearch.com/. Accessed April 2, 2019.
- 34.Lacour J-P, Paul C, Jazayeri S, et al. Secukinumab administration by autoinjector maintains reduction of plaque psoriasis severity over 52 weeks: results of the randomized controlled JUNCTURE trial. J Eur Acad Dermatol Venereol. 2017;31(5):847–56. https://doi.org/10.1111/jdv.14073.CrossRefPubMedGoogle Scholar
- 35.Reich K, Zschocke I, Bachelez H, et al. A Topical Treatment Optimization Programme (TTOP) improves clinical outcome for calcipotriol/betamethasone gel in psoriasis: results of a 64-week multinational randomized phase IV study in 1790 patients (PSO-TOP). Br J Dermatol. 2017;177(1):197–205. https://doi.org/10.1111/bjd.15466.CrossRefPubMedGoogle Scholar
- 37.Höchsmann C, Infanger D, Klenk C, Königstein K, Walz SP, Schmidt-Trucksäss A. Effectiveness of a behavior change technique–based smartphone game to improve intrinsic motivation and physical activity adherence in patients with type 2 diabetes: randomized controlled trial. JMIR Serious Games. 2019;7(1):e11444. https://doi.org/10.2196/11444.CrossRefPubMedPubMedCentralGoogle Scholar
- 40.Pillo Health. https://www.pillohealth.com/. Accessed April 2, 2019.
- 41.Schuman-Olivier Z, Borodovsky JT, Steinkamp J, et al. MySafeRx: a mobile technology platform integrating motivational coaching, adherence monitoring, and electronic pill dispensing for enhancing buprenorphine/naloxone adherence during opioid use disorder treatment: a pilot study. Addict Sci Clin Pract. 2018;13(1):21. https://doi.org/10.1186/s13722-018-0122-4.CrossRefPubMedPubMedCentralGoogle Scholar