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Different Gene Expression Profile of Mesenchymal Stem Cells from Various Sources

  • Babak ArjmandEmail author
  • Negar Ranjbaran
  • Fatemeh Khatami
  • Mehrdad Hashemi
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Mesenchymal stem cells can be derived from different tissues of the body. It is important to select the suitable tissue that has the main characteristics of these types of cells. As we know, behind each specific property, a specific gene is expressed and the molecular process is in progress. Evaluating morphology, surface markers, potency, gene expression, and differentiation potential can be helpful to choose the most appropriate cellular source. These data considered a higher expression of chondrogenesis markers in bone marrow-derived and osteogenesis markers in umbilical cord blood-derived mesenchymal stem cells, and also an increase in angiogenesis and proliferation potential of umbilical cord mesenchymal stem cells. Comprehensive information of gene expression profile of mesenchymal stem cells can make it possible to use the mesenchymal stem cells in cell therapy, pharmacological tests, tissue engineering, and also has a positive role in omics studies.

Keywords

Bone marrow Gene expression Mesenchymal stem cells Placenta Transcriptome profiles 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Babak Arjmand
    • 1
    • 2
    Email author
  • Negar Ranjbaran
    • 3
  • Fatemeh Khatami
    • 4
  • Mehrdad Hashemi
    • 3
  1. 1.Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  2. 2.Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Department of Genetics, Tehran Medical SciencesIslamic Azad UniversityTehranIran
  4. 4.Chronic Disease Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran

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