Advertisement

Severe Asthma During Adolescence and the Transition to Adulthood

  • Erick FornoEmail author
  • Sejal Saglani
Chapter

Abstract

In prior chapters of this book, we have reviewed the epidemiology of severe asthma and have discussed important considerations in the preschool years. Adolescents comprise another important and vulnerable population, in whom asthma severity may vary and many other factors, especially social influences, may affect asthma control. In this chapter we will discuss current knowledge of the natural history of severe asthma during adolescence, risk factors for poor outcomes, and important issues to consider when we manage patients in this age group and help them prepare for the transition to young adulthood – when patients are expected to become responsible for managing their disease.

Keywords

Severe asthma Difficult-to-treat asthma Asthma in adolescence Asthma disparities 

References

  1. 1.
    Belgrave DCM, Simpson A, Semic-Jusufagic A, Murray CS, Buchan I, Pickles A, et al. Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing. J Allergy Clin Immunol. 2013;132(3):575–83.e12.PubMedCrossRefGoogle Scholar
  2. 2.
    Rusconi F, Fernandes RM, Pijnenburg MWH, Grigg J, Collaboration SCR, European Lung Foundation severe asthma patient advisory g. The Severe Paediatric Asthma Collaborative in Europe (SPACE) ERS Clinical Research Collaboration: enhancing participation of children with asthma in therapeutic trials of new biologics and receptor blockers. Eur Respir J. 2018;52:4.CrossRefGoogle Scholar
  3. 3.
    Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315–23.PubMedCrossRefGoogle Scholar
  4. 4.
    Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127(2):382–9.e1–13.PubMedCrossRefGoogle Scholar
  5. 5.
    Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, et al. Baseline features of the Severe Asthma Research Program (SARP III) cohort: differences with age. J Allergy Clin Immunol Pract. 2018;6(2):545–54 e4.PubMedCrossRefGoogle Scholar
  6. 6.
    Sears MR. Predicting asthma outcomes. J Allergy Clin Immunol. 2015;136(4):829–36. quiz 37PubMedCrossRefGoogle Scholar
  7. 7.
    Covar RA, Strunk R, Zeiger RS, Wilson LA, Liu AH, Weiss S, et al. Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol. 2010;125(2):359–66.e3.PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Strachan DP, Butland BK, Anderson HR. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ. 1996;312(7040):1195–9.PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Butland BK, Strachan DP. Asthma onset and relapse in adult life: the British 1958 birth cohort study. Ann Allergy Asthma Immunol. 2007;98(4):337–43.PubMedCrossRefGoogle Scholar
  10. 10.
    Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rosler B, et al. The all age asthma cohort (ALLIANCE) – from early beginnings to chronic disease: a longitudinal cohort study. BMC Pulm Med. 2018;18(1):140.PubMedPubMedCentralCrossRefGoogle Scholar
  11. 11.
    Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349(15):1414–22.PubMedCrossRefGoogle Scholar
  12. 12.
    Tai A, Tran H, Roberts M, Clarke N, Gibson AM, Vidmar S, et al. Outcomes of childhood asthma to the age of 50 years. J Allergy Clin Immunol. 2014;133(6):1572–8 e3.PubMedCrossRefGoogle Scholar
  13. 13.
    Ross KR, Teague WG, Gaston BM. Life cycle of childhood asthma: prenatal, infancy and preschool, childhood, and adolescence. Clin Chest Med. 2019;40(1):125–47.PubMedCrossRefGoogle Scholar
  14. 14.
    Covar RA, Spahn JD, Murphy JR, Szefler SJ, Childhood Asthma Management Program Research G. Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med. 2004;170(3):234–41.PubMedCrossRefGoogle Scholar
  15. 15.
    Calhoun WJ, Haselkorn T, Miller DP, Omachi TA. Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma. J Allergy Clin Immunol. 2015;136(4):1125–7 e4.PubMedCrossRefGoogle Scholar
  16. 16.
    Tai A. Childhood asthma and chronic obstructive pulmonary disease: outcomes until the age of 50. Curr Opin Allergy Clin Immunol. 2015;15(2):169–74.PubMedCrossRefGoogle Scholar
  17. 17.
    Fuchs O, Bahmer T, Rabe KF, von Mutius E. Asthma transition from childhood into adulthood. Lancet Respir Med. 2017;5(3):224–34.PubMedCrossRefGoogle Scholar
  18. 18.
    Sawicki GS, Ostrenga J, Petren K, Fink AK, D’Agostino E, Strassle C, et al. Risk factors for gaps in care during transfer from pediatric to adult cystic fibrosis programs in the United States. Ann Am Thorac Soc. 2018;15(2):234–40.PubMedCrossRefGoogle Scholar
  19. 19.
    Bowmer G, Sowerby C, Duff A. Transition and transfer of young people with cystic fibrosis to adult care. Nurs Child Young People. 2018;30(5):34–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Connett GJ, Nagra A. Ready, steady, go – achieving successful transition in cystic fibrosis. Paediatr Respir Rev. 2018;27:13–5.PubMedGoogle Scholar
  21. 21.
    Hart LC, Patel-Nguyen SV, Merkley MG, Jonas DE. An evidence map for interventions addressing transition from pediatric to adult care: a systematic review of systematic reviews. J Pediatr Nurs. 2019;48:18–34.PubMedCrossRefGoogle Scholar
  22. 22.
    Coyne I, Sheehan AM, Heery E, While AE. Improving transition to adult healthcare for young people with cystic fibrosis: a systematic review. J Child Health Care. 2017;21(3):312–30.PubMedCrossRefGoogle Scholar
  23. 23.
    Bush A, Fleming L, Saglani S. Severe asthma in children. Respirology. 2017;22(5):886–97.PubMedCrossRefGoogle Scholar
  24. 24.
    de Benedictis D, Bush A. Asthma in adolescence: is there any news? Pediatr Pulmonol. 2017;52(1):129–38.PubMedCrossRefGoogle Scholar
  25. 25.
    Bitsko MJ, Everhart RS, Rubin BK. The adolescent with asthma. Paediatr Respir Rev. 2014;15(2):146–53.PubMedGoogle Scholar
  26. 26.
    O’Byrne PM, FitzGerald JM, Bateman ED, Barnes PJ, Zhong N, Keen C, et al. Inhaled combined budesonide-formoterol as needed in mild asthma. N Engl J Med. 2018;378(20):1865–76.PubMedCrossRefGoogle Scholar
  27. 27.
    Beasley R, Holliday M, Reddel HK, Braithwaite I, Ebmeier S, Hancox RJ, et al. Controlled trial of budesonide-formoterol as needed for mild asthma. N Engl J Med. 2019;380(21):2020–30.PubMedCrossRefGoogle Scholar
  28. 28.
    Devillier P, Humbert M, Boye A, Zachgo W, Jacques L, Nunn C, et al. Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting beta2-agonists (ICS/LABA) in patients with uncontrolled asthma: an open-label, randomized, controlled trial. Respir Med. 2018;141:111–20.PubMedCrossRefGoogle Scholar
  29. 29.
    Jensen PT, Paul GV, LaCount S, Peng J, Spencer CH, Higgins GC, et al. Assessment of transition readiness in adolescents and young adults with chronic health conditions. Pediatr Rheumatol Online J. 2017;15(1):70.PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Holley S, Knibb R, Latter S, Liossi C, Mitchell F, Radley R, et al. Development and validation of the Adolescent Asthma Self-Efficacy Questionnaire (AASEQ). Eur Respir J. 2019;54:1801375.PubMedCrossRefGoogle Scholar
  31. 31.
    Han YY, Forno E, Celedon JC. Health risk behaviors, violence exposure, and current asthma among adolescents in the United States. Pediatr Pulmonol. 2019;54:237.PubMedCrossRefGoogle Scholar
  32. 32.
    Han YY, Forno E, Marsland AL, Miller GE, Celedon JC. Depression, asthma, and bronchodilator response in a nationwide study of US adults. J Allergy Clin Immunol Pract. 2016;4(1):68–73.e1.PubMedCrossRefGoogle Scholar
  33. 33.
    Brehm JM, Ramratnam SK, Tse SM, Croteau-Chonka DC, Pino-Yanes M, Rosas-Salazar C, et al. Stress and bronchodilator response in children with asthma. Am J Respir Crit Care Med. 2015;192(1):47–56.PubMedPubMedCentralCrossRefGoogle Scholar
  34. 34.
    Priftis KN, Anthracopoulos MB. The causal relationship between stress and asthma. Allergol Immunopathol (Madr). 2008;36(6):343–6.CrossRefGoogle Scholar
  35. 35.
    Rosenberg SL, Miller GE, Brehm JM, Celedon JC. Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms. J Allergy Clin Immunol. 2014;134(5):1009–15.PubMedPubMedCentralCrossRefGoogle Scholar
  36. 36.
    Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jimenez-Ruiz CA, et al. Electronic cigarettes: a task force report from the European Respiratory Society. Eur Respir J. 2019;53(2):1801151.PubMedCrossRefGoogle Scholar
  37. 37.
    Gentzke AS, Creamer M, Cullen KA, Ambrose BK, Willis G, Jamal A, et al. Vital signs: tobacco product use among middle and high school students—United States, 2011-2018. MMWR Morb Mortal Wkly Rep. 2019;68(6):157–64.PubMedPubMedCentralCrossRefGoogle Scholar
  38. 38.
    Reid KM, Forrest JR, Porter L. Tobacco product use among youths with and without lifetime asthma – Florida, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(21):599–601.PubMedPubMedCentralCrossRefGoogle Scholar
  39. 39.
    Bayly JE, Bernat D, Porter L, Choi K. Secondhand exposure to aerosols from electronic nicotine delivery systems and asthma exacerbations among youth with asthma. Chest. 2019;155(1):88–93.PubMedCrossRefGoogle Scholar
  40. 40.
    Cho JH, Paik SY. Association between electronic cigarette use and asthma among high school students in South Korea. PLoS One. 2016;11(3):e0151022.PubMedPubMedCentralCrossRefGoogle Scholar
  41. 41.
    van den Toorn LM, Overbeek SE, de Jongste JC, Leman K, Hoogsteden HC, Prins JB. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med. 2001;164(11):2107–13.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Pediatric Pulmonary MedicineChildren’s Hospital of PittsburghPittsburghUSA
  2. 2.Department of PediatricsUniversity of Pittsburgh School of MedicinePittsburghUSA
  3. 3.Paediatric Respiratory MedicineNational Heart & Lung Institute, Imperial College LondonLondonUK
  4. 4.Department of Respiratory PaediatricsRoyal Brompton HospitalLondonUK

Personalised recommendations