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Restoring Vision Using Stem Cells and Transplantation

  • Elisa Cuevas
  • Paresh Parmar
  • Jane C. SowdenEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1185)

Abstract

The replacement of retinal cells, or the support of surviving retinal neurons, in a degenerated retina presents a significant challenge in the fields of ophthalmology and regenerative medicine. Stem cell-based therapies are being explored as an approach for treating retinal dystrophies, such as retinitis pigmentosa (RP), Stargardt’s disease, and age-related macular degeneration (AMD). This review provides an update on the recent progress made toward the restoration of vision lost to degenerative disease using stem cell-based transplantation strategies and the challenges that need to be overcome. Both retinal pigmented epithelium (RPE) and photoreceptor replacement therapies are discussed.

Keywords

Cell therapy Cell transplantation Retinal degeneration Retinitis pigmentosa Age-related macular disease Stem cell therapy Retinal organoids Translational research In vitro retinal pigmented epithelium In vitro photoreceptor cells 

Notes

Acknowledgment

This work was supported by the MRC UK grant MR/M015688/1, GOSHCC, and the NIHR.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Stem Cells and Regenerative Medicine Section, University College London Great Ormond Street Institute of Child Health, and NIHR Great Ormond Street Hospital Biomedical Research CentreLondonUK

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