Glioma Imaging pp 211-221 | Cite as

FET and FDOPA PET Imaging in Glioma

  • Norbert GalldiksEmail author
  • Philipp Lohmann
  • Francesco Cicone
  • Karl-Josef Langen


Metabolic imaging techniques such as positron emission tomography (PET) can characterize specific metabolic and cellular features of gliomas which may provide clinically relevant information beyond structural magnetic resonance imaging (MRI). In contrast to the widely used PET tracer 2-[18F]fluoro-2-deoxy-D-glucose (FDG), the uptake of radiolabeled amino acids such as O-(2-[18F]fluoroethyl)-L-tyrosine (FET) or 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (FDOPA) is low in normal brain tissue, and brain tumors can be depicted with high contrast. Like FDG, these amino acid tracers are able to cross the intact blood-brain barrier, which allows the depiction of the tumor extent beyond the contrast-enhancing region of conventional MRI. Recently, the Response Assessment in Neuro-Oncology (RANO) working group – an international effort to develop new standardized response criteria for clinical trials in brain tumors – has recommended the additional use of amino acid PET imaging for brain tumor management, especially for the delineation of the tumor extent, differentiation of treatment-related changes from tumor progression, and the assessment of treatment response.


FDG PET FET PET FDOPA PET Amino acid PET Dynamic PET acquisition 


Disclosure of Potential Conflicts of Interest

Related to the present work, all authors report no conflicts of interest.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Norbert Galldiks
    • 1
    • 2
    • 3
    Email author
  • Philipp Lohmann
    • 2
  • Francesco Cicone
    • 4
    • 5
  • Karl-Josef Langen
    • 2
    • 6
    • 7
  1. 1.Department of NeurologyUniversity Hospital CologneCologneGermany
  2. 2.Institute of Neuroscience and Medicine (INM-3, -4), Research Center JuelichJuelichGermany
  3. 3.Center of Integrated Oncology (CIO), Universities of Aachen, Bonn, Cologne, and DuesseldorfCologneGermany
  4. 4.Department of Nuclear Medicine and Molecular ImagingLausanne University HospitalLausanneSwitzerland
  5. 5.Unit of Nuclear Medicine, Sant’ Andrea Hospital, Sapienza University of RomeRomeItaly
  6. 6.Department of Nuclear MedicineUniversity of AachenAachenGermany
  7. 7.Juelich-Aachen Research Alliance (JARA) - Section JARA-BrainJuelichGermany

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