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Effect of Process Conditions on the Morphological Characteristics of Particles Obtained by Supercritical Antisolvent Precipitation

  • Diego T. SantosEmail author
  • Ádina L. Santana
  • M. Angela A. Meireles
  • Ademir José Petenate
  • Eric Keven Silva
  • Juliana Q. Albarelli
  • Júlio C. F. Johner
  • M. Thereza M. S. Gomes
  • Ricardo Abel Del Castillo Torres
  • Tahmasb Hatami
Chapter
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)

Abstract

A supercritical particle formation equipment, designed and constructed by our research group, was validated in this study using supercritical CO2 as an antisolvent. Ibuprofen sodium salt was successfully micronized by supercritical antisolvent (SAS) precipitation. Ethanol and CO2 was used as solvent and antisolvent, respectively, and the effect of the operating conditions on the precipitation yield, residual organic solvent content and particle morphology were evaluated using a split-plot experimental design and the analysis of variance (ANOVA) method. This study showed that when selecting appropriate process conditions, it is possible to produce a sheet-like morphology, which is the best for tableting purposes, with high precipitation yield (70%) and low residual solvent content (4.7 mg kg−1).

Notes

Acknowledgements

The authors are grateful to CNPq (470916/2012-5) and FAPESP (2012/10685-8) for their financial support. M. Thereza M. G. Rosa and Eric Keven Silva thanks CNPq (140641/2011-4 and 140275/2014-2) for the Ph.D. assistantship. Diego T. Santos thanks the FAPESP (10/16485-5; 12/19304-7) and CAPES for the postdoctoral fellowships. M. Angela A. Meireles thanks CNPq for a productivity grant (301301/2010-7). The authors also thank Moyses N. Moraes for his assistance with the statistical analyses.

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Copyright information

© The Author(s), under exclusive license to Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Diego T. Santos
    • 1
    Email author
  • Ádina L. Santana
    • 2
  • M. Angela A. Meireles
    • 3
  • Ademir José Petenate
    • 4
  • Eric Keven Silva
    • 5
  • Juliana Q. Albarelli
    • 6
  • Júlio C. F. Johner
    • 7
  • M. Thereza M. S. Gomes
    • 8
  • Ricardo Abel Del Castillo Torres
    • 9
  • Tahmasb Hatami
    • 10
  1. 1.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  2. 2.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  3. 3.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  4. 4.Process ImprovementEDTICampinasBrazil
  5. 5.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  6. 6.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  7. 7.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  8. 8.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  9. 9.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil
  10. 10.LASEFI/DEA, School of Food EngineeringUniversity of Campinas—UNICAMPCampinasBrazil

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