CT Perfusion Techniques and Applications in Stroke and Cancer

  • Ting-Yim LeeEmail author
  • Dae Myoung Yang
  • Fiona Li
  • Raanan Marants


CT perfusion is a functional imaging modality that has gained increasing use in imaging acute ischemic stroke patients to select patients for appropriate treatment with either thrombolysis or thrombectomy and in imaging cancer to confirm diagnosis and monitor progress of treatment. The advantages of CT perfusion are around-the-clock accessibility and easy implementation in most imaging departments. The discussion in this chapter will focus on four areas: (1) physiological models of contrast transport in tissue, (2) deconvolution techniques to derive functional parameters from the physiological models, (3) optimization of scanning protocols with respect to radiation dose and accuracy of derived functional parameters, and (4) application examples in stroke and cancer.


Physiological modeling Deconvolution Singular value decomposition Delay-insensitive deconvolution Blood flow Blood volume Mean transit time Permeability surface product 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ting-Yim Lee
    • 1
    Email author
  • Dae Myoung Yang
    • 2
  • Fiona Li
    • 2
  • Raanan Marants
    • 2
  1. 1.Imaging Program, Lawson Health Research Institute & Robarts Research Institute, Medical Biophysics, Medical Imaging and OncologyThe University of Western OntarioLondonCanada
  2. 2.Medical BiophysicsThe University of Western OntarioLondonCanada

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