CT as a Functional Imaging Technique

  • Jonathan W. Revels
  • Achille Mileto


As the growing human population continues to age, there is an increasing incidence of chronic diseases, such as cancer and coronary artery disease. Traditionally, conditions such as these have required multimodality imaging (i.e., CT, MRI, PET/CT, and ultrasound) to both initially diagnose and monitor for response after initiation of therapy. However, the wide availability, growing technologic advances, and ongoing research have allowed for CT to leap forward from a modality traditionally grounded in purely anatomic imaging to one with the capability of yielding clinically relevant functional information on par with that of other radiologic exams. In this chapter, we provide an overview of CT sub-modalities and applications highlighting and placing emphasis on how CT imaging can transition from a merely anatomic to a functional imaging modality.


CT Dual-energy CT Functional imaging Oncologic imaging Material decomposition Cellular tracking 



Thank you to Dr. Ryan O’Malley for contributing a CT case of pancreatic tumor perfusion.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Jonathan W. Revels
    • 1
  • Achille Mileto
    • 2
  1. 1.Department of Radiology, Division of Body and Thoracic ImagingUniversity of New MexicoAlbuquerqueUSA
  2. 2.Department of Radiology, Division of Body ImagingUniversity of WashingtonSeattleUSA

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