Diagnosis and Management of Clostridium difficile Infection (CDI)

  • Paul C. JohnsonEmail author
  • Minh Le
  • Matthew D. Sims
  • Paul D. Bozyk


Infection due to Clostridium difficile is a prevalent cause of morbidity and mortality in the intensive care unit. Appropriate diagnosis and treatment of CDI remains challenging in the face of new methods of detection and emerging management strategies. We describe CDI symptoms, epidemiology, diagnosis, medical therapy, and surgical interventions for treatment. A review of upcoming modalities of therapy is additionally detailed.


Clostridium difficile Infection CDI CDAD Diarrhea Treatment Diagnosis Megacolon Fecal transplant 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Paul C. Johnson
    • 1
    Email author
  • Minh Le
    • 2
  • Matthew D. Sims
    • 1
  • Paul D. Bozyk
    • 2
  1. 1.Section of Infectious Diseases and International MedicineBeaumont HealthRoyal OakUSA
  2. 2.Section of Pulmonary, Critical Care, and Sleep MedicineBeaumont HealthRoyal OakUSA

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