Mastocytosis is divided into the systemic and skin-limited forms. The main subtypes of pediatric cutaneous mastocytosis include maculopapular cutaneous mastocytosis which includes urticaria pigmentosa, mastocytoma and diffuse cutaneous mastocytosis.
The presence of an elevated serum total tryptase level (≥20 ng/mL) reflects more extensive skin disease, higher risk of severe mast cell activation, and possible systemic involvement
Physical stimuli, emotional factors, infection, drugs and food may activate mast cells
In children, common triggers include temperature changes, irritability, fever and teething
Medications that may be effective in the treatment of cutaneous mastocytosis include H1 and H2 antihistamines, mast cell stabilizers like cromolyn sodium and leukotriene antagonists
KeywordsMastocytosis Urticaria pigmentosa Mastocytoma Antihistamines Cromolyn sodium
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