Hyperpigmented Patches

  • Yan Ling Kong
  • Emily Yiping Gan


  • Mastocytosis is divided into the systemic and skin-limited forms. The main subtypes of pediatric cutaneous mastocytosis include maculopapular cutaneous mastocytosis which includes urticaria pigmentosa, mastocytoma and diffuse cutaneous mastocytosis.

  • The presence of an elevated serum total tryptase level (≥20 ng/mL) reflects more extensive skin disease, higher risk of severe mast cell activation, and possible systemic involvement

  • Physical stimuli, emotional factors, infection, drugs and food may activate mast cells

  • In children, common triggers include temperature changes, irritability, fever and teething

  • Medications that may be effective in the treatment of cutaneous mastocytosis include H1 and H2 antihistamines, mast cell stabilizers like cromolyn sodium and leukotriene antagonists


Mastocytosis Urticaria pigmentosa Mastocytoma Antihistamines Cromolyn sodium 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Yan Ling Kong
    • 1
  • Emily Yiping Gan
    • 2
  1. 1.National Skin CentreSingaporeSingapore
  2. 2.Dermatology ServiceKK Women’s and Children’s HospitalSingaporeSingapore

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