Advertisement

Blisters on Back and Upper Extremities

  • Gulsen Akoglu
Chapter

Abstract

  • Pemphigus vulgaris is the most common type of pemphigus with mucocutaneous and mucosal variants

  • Pemphigus foliaceus presents with superficial flaccid blisters and scales with anti desmoglein 1 antibody

  • Pemphigus vegetans presents with vegetative and papillomatous lesions and pemphigus herpetiformis with grouped and herpetiform small blisters, without papillary dermal antidesmogelin 1 antibody deposits

  • Paraneoplastic pemphigus is associated with underlying malignancy and more severe painful oral lesions

  • Drug-induced types of pemphigus may be triggered by exposure to thiol drugs, such a D-penicillamine and captopril, phenol drugs, or non-thiol non-phenol drugs such as peniciline and cephalosporines

Keywords

Pemphigus vulgaris Pemphigus foliaceus Pemphigus vegetans d-penicillamine 

References

  1. 1.
    Jukic IL, Marinovic B. Significance of immunofluorescence in the diagnosis of autoimmune bullous dermatoses. Clin Dermatol. 2011;29(4):389–97.CrossRefGoogle Scholar
  2. 2.
    Mihalyi L, Kiss M, Dobozy A, Kemeny L, Husz S. Clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis. Clin Dev Immunol. 2012;2012:369546.CrossRefGoogle Scholar
  3. 3.
    Ishii K. Importance of serological tests in diagnosis of autoimmune blistering diseases. J Dermatol. 2015;42(1):3–10.CrossRefGoogle Scholar
  4. 4.
    Yoshimura K, Ishii N, Hamada T, Abe T, Ono F, Hashikawa K, Fukuda S, Ohyama B, Koga H, Sogame R, Teye K, Ochiai T, Nakajima H, Nakajima K, Iijima S, Kanzaki M, Kojima K, Nagatani T, Fujimoto W, Karashima T, Nakama T, Ohata C, Furumura M, Tsuruta D, Hashimoto T. Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. Br J Dermatol. 2014;171(3):544–53.CrossRefGoogle Scholar
  5. 5.
    Kozlowska A, Hashimoto T, Jarzabek-Chorzelska M, Amagai A, Nagata Y, Strasz Z, Jablonska S. Pemphigus herpetiformis with IgA and IgG antibodies to desmoglein 1 and IgG antibodies to desmocollin 3. J Am Acad Dermatol. 2003;48(1):117–22.CrossRefGoogle Scholar
  6. 6.
    Ruocco V, De Angelis E, Lombardi ML. Drug-induced pemphigus. II. Pathomechanisms and experimental investigations. Clin Dermatol. 1993;11(4):507–13.CrossRefGoogle Scholar
  7. 7.
    Ruocco E, Wolf R, Ruocco V, Brunetti G, Romano F, Lo Schiavo A. Pemphigus: associations and management guidelines: facts and controversies. Clin Dermatol. 2013;31(4):382–90.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Gulsen Akoglu
    • 1
  1. 1.Gulhane Training and Research Hospital, Dermatology and Venereology ClinicUniversity of Health SciencesAnkaraTurkey

Personalised recommendations