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Annular Blisters and Erosions

  • Soner UzunEmail author
  • Aslı Bilgic-Temel
Chapter

Abstract

  • Pemphigus is rare in children and called juvenile pemphigus

  • The intraepithelial blister formation in pemphigus is caused by IgG autoantibodies against the desmosomal adhesion proteins, desmoglein 3 and/or desmoglein 1, on epidermal keratinocytes

  • Direct immunofluorescence is considered the gold standard in diagnosis of pemphigus

  • Prognosis of untreated pemphigus foliaceous is much better than pemphigus vulgaris. This is due to lower rate of infection and metabolic disorders and low potential for fluid loss

Keywords

Desmoglein Pemphigus Direct immunofluorescence 

References

  1. 1.
    Küçükoglu RB, Babuna G. The clinical diagnosis of autoimmune bullous diseases. Türkderm. 2011;45:16–25.CrossRefGoogle Scholar
  2. 2.
    Ioannides D, Lazaridou E, Rigopoulos D. Pemphigus. J Eur Acad Dermatol Venereol. 2008;22(12):1478–96.CrossRefGoogle Scholar
  3. 3.
    Marathe K, Lu J, Morel K. Bullous diseases: kids are not just little people. Clin Dermatol. 2015;33(6):644–56.CrossRefGoogle Scholar
  4. 4.
    Uzun S, Durdu M, Akman A, Gunasti S, Uslular C, Memisoglu H, Alpsoy E. Pemphigus in the Mediterranean region of Turkey: a study of 148 cases. Int J Dermatol. 2006;45(5):523–8.CrossRefGoogle Scholar
  5. 5.
    Haber H. Cytodiagnosis in dermatology. Br J Dermatol. 1954;66:79–94.CrossRefGoogle Scholar
  6. 6.
    Yazganoğlu KD, Baykal C, Küçükoğlu R. Childhood pemphigus vulgaris: five cases in 16 years. J Dermatol. 2006;33:846–9.CrossRefGoogle Scholar
  7. 7.
    Ruocco V. Cytodiagnosis in dermatology. Naples: Cooperativa Libraria Universitaria; 1980. p. 20–110.Google Scholar
  8. 8.
    Blank H, Burgoon C. Abnormal cytology of epithelial cells in pemphigus vulgaris: a diagnostic aid. J Invest Dermatol. 1952;18:213–23.CrossRefGoogle Scholar
  9. 9.
    Durdu M, Baba M, Seçkin D. The value of Tzanck smear test in diagnosis of erosive, vesicular, bullous, and pustular skin lesions. J Am Acad Dermatol. 2008;59(6):958–64.CrossRefGoogle Scholar
  10. 10.
    Erkin G. The histopathological diagnosis of autoimmune bullous diseases. Türkderm. 2011;45(Special edition 1):26–30.CrossRefGoogle Scholar
  11. 11.
    Elston D, Ferringer T, Ko C, Peckham S, High W, DiCaudo D. Blistering diseases. In: Dermatopathology. 2nd ed. Philadelphia: Elsevier Ltd.; 2009.Google Scholar
  12. 12.
    Probst C, Schlumberger W, Stöcker W, Recke A, Schmidt E, Hashimoto T, Zhu XJ, Zillikens D, Komorowsk L. Development of ELISA for the specific determination of autoantibodies against envoplakin and periplakin in paraneoplastic pemphigus. Clin Chim Acta. 2009;410(1–2):13–8.CrossRefGoogle Scholar
  13. 13.
    Remington J, Chen M, Burnett J, Woodley D. Autoimmunity to type VII collagen: epidermolysis bullosa acquisita. Curr Dir Autoimmun. 2008;10:195–205.CrossRefGoogle Scholar
  14. 14.
    Bekou V, Thoma-Uszynski S, Wendler O, Uter W, Schwietzke S, Hunziker T, Zouboulis C, Schuler G, Sorokin L, Hertl M. Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA. J Invest Dermatol. 2005;124(4):732–40.CrossRefGoogle Scholar
  15. 15.
    Amagai M, Komai A, Hashimoto T, Shirakata Y, Hashimoto K, Yamada T, Kitajima Y, Ohya K, Iwanami H, Nishikawa T. Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br J Dermatol. 1999;140(2):351–7.CrossRefGoogle Scholar
  16. 16.
    Sitaru C, Dahnrich C, Probst C, Komorowski L, Blocker I, Schmidt E, Schlumberger W, Rose C, Stocker W, Zillikens D. Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies. Exp Dermatol. 2007;16(9):770–7.CrossRefGoogle Scholar
  17. 17.
    Uzun S. Dermatolojide immünofloresan teknikler. Deri Sorunlarında Adım Adım Tanısal Yaklaşımlar. Istanbul: Mart Matbaacılık; 2006.Google Scholar
  18. 18.
    Mutasim D, Adams B. Immunofluorescence in dermatology. J Am Acad Dermatol. 2001;45(6):803–22.CrossRefGoogle Scholar
  19. 19.
    Uzun S. Immunofluoresecence findings in the diagnosis of autoimmune bullous diseases. Türkderm. 2011;45(Special edition 1):31–5.CrossRefGoogle Scholar
  20. 20.
    James W, Berger T, Elston D. Andrew’s diseases of the skin clinical dermatology. Canada: Saunders Elsevier; 2006.Google Scholar
  21. 21.
    Wien MH. Pemhigus. In: Wien MH, editor. Autoimmune diseases of the skin. Vienna: Springer; 2005.Google Scholar
  22. 22.
    Bystryn J, Rudolph J. Pemphigus. Lancet (London, England). 2005;366:61–73.CrossRefGoogle Scholar
  23. 23.
    Uzun S. Current management of pemphigus: review. Turk J Dermatol. 2012;6:91–101.CrossRefGoogle Scholar
  24. 24.
    Kasperkiewicz M, Schmidt E, Zillikens D. Current therapy of the pemphigus group. Clin Dermatol. 2012;30(1):84–94.CrossRefGoogle Scholar
  25. 25.
    Werth VP, Fivenson D, Pandya AG, Chen D, Rico MJ, Albrecht J, Jacobus D. Multicenter randomized, double-blind, placebo-controlled, clinical trial of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris. Arch Dermatol. 2008;144(1):25–32.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Dermatology and Venereology, School of MedicineAkdeniz UniversityAntalyaTurkey
  2. 2.Seydisehir State Hospital, Dermatology ClinicKonyaTurkey

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