Acute Dyspnea After Platelet Transfusion
Transfusion-associated lung injury (TRALI) is defined as the onset of acute, non-cardiogenic pulmonary edema within 6 h of transfusion and the absence of pre-existing acute lung injury
Diagnostic findings are hypoxia (O2 saturation < 90% in room air), a PaO2/FiO2 ratio < 300 mmHg and new bilateral pulmonary infiltrates.
With O2 supplementation, up to 72% of cases of TRALI resolve within 48–96 h
High dose steroids have no benefit in TRALI
KeywordsTransfusion-associated lung injury Pulmonary edema Acute lung injury FiO2
- 1.Kleinman S, Povosky M. TRALI: mechanisms, management and prevention. Bethseda: AABB Press; 2008.Google Scholar