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DOCK8 Deficiency and No Matched Donor

  • Beatriz Morillo-Gutierrez
  • Mary SlatterEmail author
Chapter

Abstract

  • Hematopoietic stem cell transplantation is still the only curative treatment for many primary immunodeficiencies

  • HSCT has the best outcome if performed before the development of potential comorbidities

  • Nowadays, the lack of a matched donor must not be a limitation, thanks to the availability of new techniques to avoid graft versus host disease, such as CD3+TCRαβ+/CD19+ depletion technique used here

Keywords

Dedicator of cytokinesis Hematopoietic stem cell transplantation Graft versus host disease 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Translational Paediatrics and Infectious Diseases UnitSantiago de Compostela University HospitalSantiago de CompostelaSpain
  2. 2.Department of Paediatric ImmunologyGreat North Children’s Hospital, Royal Victoria InfirmaryNewcastle upon TyneUK
  3. 3.Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneUK

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