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Linkage Disequilibrium Between HLA Alleles in Hematopoietic Stem Cell Transplantation

  • Soumya Pandey
  • Terry HarvilleEmail author
Chapter

Abstract

  • Linkage disequilibrium is the concept that HLA types are associated into inherited haplotypes more commonly than is expected from DNA crossover events, which occur during normal meiosis

  • The distal HLA loci HLA-DP and HLA-A may have some of the greatest chances to undergo crossover exchanges, due to being at the opposite extreme ends of the HLA locus on the short arm of chromosome six

  • If the HLA-A, -B, -C, and -DR are known, then -DQ can be predicted with reasonable accuracy, and likewise if HLA-A, -B, -C, -DR, and -DQ are known, the -DP may be predicted, albeit with somewhat less accuracy

Keywords

Hematopoietic cell transplantation (HCT) Linkage disequilibrium Cross-over HLA-DP HLA-DQ 

References

  1. 1.
    Spellman S, Setterholm M, Maiers M, Noreen H, Oudshoorn M, Fernandez-Vina M, Petersdorf E, Bray R, Hartzman RJ, Ng J, Hurley CK. Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry. Biol Blood Marrow Transpl. 2008;14(9 Suppl):37–44.CrossRefGoogle Scholar
  2. 2.
    Pidala J, Lee SJ, Ahn KW, Spellman S, Wang HL, Aljurf M, Askar M, Dehn J, Fernandez Vina M, Gratwohl A, Gupta V, Hanna R, Horowitz MM, Hurley CK, Inamoto Y, Kassim AA, Nishihori T, Mueller C, Oudshoorn M, Petersdorf EW, Prasad V, Robinson J, Saber W, Schultz KR, Shaw B, Storek J, Wood WA, Woolfrey AE, Anasetti C. Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood. 2014;124(16):2596–606.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory ServicesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Pediatrics and Internal MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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