Discrepant Cytomegalovirus Serology Between Donor and Recipient in Hematopoietic Stem Cell Transplantation

  • Soumya Pandey
  • Terry HarvilleEmail author


  • If the recipient of hematopoietic stem cell transplantation is cytomegalovirus (CMV) negative, a CMV negative donor is preferred since this will greatly reduce the risk of subsequent reactivation of CMV and infection with CMV

  • If the recipient is CMV positive, a CMV positive donor is used with the hope that this will result in a faster restoration of anti-CMV immunity, due to the passive transfer of anti-CMV immunity from the donor to the recipient


Hematopoietic stem cell transplantation Cytomegalovirus Donor Recipient 


  1. 1.
    Bray RA, Hurley CK, Kamani NR, Woolfrey A, Muller C, Spellman S, Setterholm M, Confer DL. National marrow donor program HLA matching guidelines for unrelated adult donor hematopoietic cell transplants. Biol Blood Marrow Transpl. 2008;14(9 Suppl):45–53.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory ServicesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Departments of Pediatrics and Internal MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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