Annular Rash in a Neonate

  • Yan Ling Kong
  • Emily Yiping Gan


  • Neonatal lupus erythematosus (NLE) is an acquired autoimmune disease resulting from the transplacental passage of maternal antibodies

  • NLE is characterized by the presence of annular erythematous plaques seen predominantly on the face and scalp

  • Anti-Ro/SSA antibody in the most common auto-antibody found in patients with NLE

  • Other associated antibodies include anti-La/SSB and anti-U1RNP antibodies

  • Life-threatening cardiac conduction defects commonly occurs in NLE

  • Pacemaker insertion is usually required for patients with NLE and congenital heart block

  • Use of hydroxychloroquine decreases the risk of cardiac NLE in subsequent offspring, but not the non-cardiac manifestations of NLE


Neonatal lupus erythematosus Anti-Ro Congenital heart block 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Yan Ling Kong
    • 1
  • Emily Yiping Gan
    • 2
  1. 1.National Skin CentreSingaporeSingapore
  2. 2.Dermatology ServiceKK Women’s and Children’s HospitalSingaporeSingapore

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