The Microenvironment in Follicular Lymphoma

  • Nahum Puebla-Osorio
  • Paolo Strati
  • Sattva S. NeelapuEmail author


Current understanding of the pathogenesis of follicular lymphoma (FL) requires in-depth knowledge of the multiple cellular components of its microenvironment, including infiltrating lymphocytes, macrophages, and stromal cells, in addition to tumoral B-lymphocytes. Evidence shows that non-lymphomatous cells within the tumor microenvironment play an essential role, including impairment in antitumor immune response (IR) and promotion of immune tolerance, representing a highly relevant area of research focus for the development of novel strategies to improve clinical outcomes in this disease. In this chapter, we highlight the most prominent discoveries in the last couple of decades on the role of the tumor microenvironment in FL and provide a perspective on the discovery of novel immune targets and the development of new immune therapies for the treatment of patients with FL.


Follicular lymphoma Tumor microenvironment Follicular dendritic cells (FDCs) Follicular T helper cells Regulatory T-cells (Tregs) Stromal cells Macrophages 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Nahum Puebla-Osorio
    • 1
  • Paolo Strati
    • 1
  • Sattva S. Neelapu
    • 1
    Email author
  1. 1.Department of Lymphoma and MyelomaUniversity of Texas MD Anderson Cancer CenterHoustonUSA

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