Osteosarcopenia as a Lipotoxic Disease

  • Ahmed Al Saedi
  • Craig A. Goodman
  • Damian E. Myers
  • Alan Hayes
  • Gustavo DuqueEmail author


Osteosarcopenia, a combination of osteoporosis and sarcopenia is characterized by a synchronic loss of bone mineral density and muscle mass, which affects an important subset of frail individuals at higher risk of institutionalization, falls and fractures. This condition has been associated with fat accumulation in bone and muscles. This fat negatively impacts cell function and structure through secretion of free fatty acids and adipokines; a phenomenon called lipotoxicity. The aim of this chapter is to summarize the role of fat infiltration in the pathogenesis of osteosarcopenia including the pathways that are affected by adipocyte-secreted factors. This chapter will also explore the current and future therapeutic implications of targeting fat infiltration and lipotoxicity in osteosarcopenia.


Aging Sarcopenia Osteoporosis Osteosarcopenia Autophagy Apoptosis Lipotoxicity Palmitate Rapamycin 



Autophagy proteins


Bone Marrow


Bone mineral content


Bone mineral density


Bone morphogenetic protein


Bone marrow-derived mesenchymal stem cell


BCL2/adenovirus E1B 19 kDa protein-interacting protein 3


Extracellular signal-regulated kinases


Free Fatty Acids


High-density lipoproteins


High fat diet


High sugar diet


C-Jun N-terminal kinases


Microtubule-associated protein light chain


Low-density lipoproteins


Lipoprotein lipase


Palmitic acid


Tricarboxylic Acid


UNC-51-like Kinase


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Australian Institute for Musculoskeletal Science (AIMSS)The University of Melbourne and Western HealthSt. AlbansAustralia
  2. 2.Department of Medicine-Western Health, Melbourne Medical SchoolThe University of MelbourneSt. AlbansAustralia
  3. 3.Institute of Health and SportVictoria UniversityMelbourneAustralia
  4. 4.Institute for Health and Sport (IHES)Victoria UniversityMelbourneAustralia
  5. 5.Department of Medicine-Western HealthThe University of MelbourneSt. AlbansAustralia

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