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Plaque Erosion

  • Vikas Thondapu
  • Peter Libby
  • Ik-Kyung JangEmail author
Chapter

Abstract

Plaque rupture and erosion are the two most common causes of acute coronary syndromes (ACS). Although plaque rupture has been well-characterized by autopsy and clinical studies, current knowledge of plaque erosion remains poor. A combination of insights from autopsy, in vitro pathobiology, and in vivo optical coherence tomography (OCT) imaging studies has led to the understanding that plaques prone to rupture and erosion are fundamentally different. Consequently, their optimal management may also differ. Early clinical studies suggest that, in a carefully selected subset of patients with plaque erosion as detected by OCT, treatment with anti-thrombotic therapy alone may be a feasible and safe alternative to stent placement. Further well-powered prospective studies are necessary to investigate such tailored treatment of ACS due to plaque erosion and rupture.

Keywords

Plaque erosion Intact fibrous cap Plaque rupture Acute coronary syndrome Optical coherence tomography Neutrophil extracellular trap 

References

  1. 1.
    Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, Ahmed M, Aksut B, Alam T, Alam K, Alla F, Alvis-Guzman N, Amrock S, Ansari H, Arnlov J, Asayesh H, Atey TM, Avila-Burgos L, Awasthi A, Banerjee A, Barac A, Barnighausen T, Barregard L, Bedi N, Belay Ketema E, Bennett D, Berhe G, Bhutta Z, Bitew S, Carapetis J, Carrero JJ, Malta DC, Castaneda-Orjuela CA, Castillo-Rivas J, Catala-Lopez F, Choi JY, Christensen H, Cirillo M, Cooper L Jr, Criqui M, Cundiff D, Damasceno A, Dandona L, Dandona R, Davletov K, Dharmaratne S, Dorairaj P, Dubey M, Ehrenkranz R, El Sayed Zaki M, Faraon EJA, Esteghamati A, Farid T, Farvid M, Feigin V, Ding EL, Fowkes G, Gebrehiwot T, Gillum R, Gold A, Gona P, Gupta R, Habtewold TD, Hafezi-Nejad N, Hailu T, Hailu GB, Hankey G, Hassen HY, Abate KH, Havmoeller R, Hay SI, Horino M, Hotez PJ, Jacobsen K, James S, Javanbakht M, Jeemon P, John D, Jonas J, Kalkonde Y, Karimkhani C, Kasaeian A, Khader Y, Khan A, Khang YH, Khera S, Khoja AT, Khubchandani J, Kim D, Kolte D, Kosen S, Krohn KJ, Kumar GA, Kwan GF, Lal DK, Larsson A, Linn S, Lopez A, Lotufo PA, El Razek HMA, Malekzadeh R, Mazidi M, Meier T, Meles KG, Mensah G, Meretoja A, Mezgebe H, Miller T, Mirrakhimov E, Mohammed S, Moran AE, Musa KI, Narula J, Neal B, Ngalesoni F, Nguyen G, Obermeyer CM, Owolabi M, Patton G, Pedro J, Qato D, Qorbani M, Rahimi K, Rai RK, Rawaf S, Ribeiro A, Safiri S, Salomon JA, Santos I, Santric Milicevic M, Sartorius B, Schutte A, Sepanlou S, Shaikh MA, Shin MJ, Shishehbor M, Shore H, Silva DAS, Sobngwi E, Stranges S, Swaminathan S, Tabares-Seisdedos R, Tadele Atnafu N, Tesfay F, Thakur JS, Thrift A, Topor-Madry R, Truelsen T, Tyrovolas S, Ukwaja KN, Uthman O, Vasankari T, Vlassov V, Vollset SE, Wakayo T, Watkins D, Weintraub R, Werdecker A, Westerman R, Wiysonge CS, Wolfe C, Workicho A, Xu G, Yano Y, Yip P, Yonemoto N, Younis M, Yu C, Vos T, Naghavi M, Murray C. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1–25.PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, Kato K, Yonetsu T, Vergallo R, Hu S, Tian J, Lee H, Park SJ, Jang YS, Raffel OC, Mizuno K, Uemura S, Itoh T, Kakuta T, Choi SY, Dauerman HL, Prasad A, Toma C, McNulty I, Zhang S, Yu B, Fuster V, Narula J, Virmani R, Jang IK. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62(19):1748–58.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Hayashi T, Kiyoshima T, Matsuura M, Ueno M, Kobayashi N, Yabushita H, Kurooka A, Taniguchi M, Miyataka M, Kimura A, Ishikawa K. Plaque erosion in the culprit lesion is prone to develop a smaller myocardial infarction size compared with plaque rupture. Am Heart J. 2005;149(2):284–90.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Sugiyama T, Yamamoto E, Bryniarski K, Xing L, Lee H, Isobe M, Libby P, Jang IK. Nonculprit plaque characteristics in patients with acute coronary syndrome caused by plaque erosion vs plaque rupture: a 3-vessel optical coherence tomography study. JAMA Cardiol. 2018;3(3):207–14.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Farb A, Burke AP, Tang AK, Liang Y, Mannan P, Smialek JE, Virmani R. Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death. Circulation. 1996;93:1354–63.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Xing L, Yamamoto E, Sugiyama T, Jia H, Ma L, Hu S, Wang C, Zhu Y, Li L, Xu M, Liu H, Bryniarski K, Hou J, Zhang S, Lee H, Yu B, Jang IK. EROSION study (effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion): a 1-year follow-up report. Circ Cardiovasc Interv. 2017;10(12):e005860.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Pasterkamp G, den Ruijter HM, Libby P. Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease. Nat Rev Cardiol. 2017;14(1):21–9.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Libby P, Pasterkamp G, Crea F, Jang IK. Reassessing the mechanisms of acute coronary syndromes. Circ Res. 2019;124(1):150–60.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture of erosion of thombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89:36–44.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Burke A, Farb A, Malcom GT, Liang Y, Smialek JE, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276–82.PubMedPubMedCentralCrossRefGoogle Scholar
  11. 11.
    Burke A, Farb A, Malcom GT, Liang Y, Smialek JE, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97:2110–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Arbustini E, Dal Bello B, Morbini P, Burke A, Bocciarelli M, Specchia G, Virmani R. Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction. Heart. 1999;82:269–72.PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Kolodgie FD, Burke AP, Farb A, Weber DK, Kutys R, Wight TN, Virmani R. Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque Erosion. Arterioscler Thromb Vasc Biol. 2002;22:1642–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Sato Y, Hatakeyama K, Yamashita A, Marutsuka K, Sumiyoshi A, Asada Y. Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans. Heart. 2005;91(4):526–30.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Schwartz RS, Burke A, Farb A, Kaye D, Lesser JR, Henry TD, Virmani R. Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol. 2009;54(23):2167–73.PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Kramer MC, Rittersma SZ, de Winter RJ, Ladich ER, Fowler DR, Liang YH, Kutys R, Carter-Monroe N, Kolodgie FD, van der Wal AC, Virmani R. Relationship of thrombus healing to underlying plaque morphology in sudden coronary death. J Am Coll Cardiol. 2010;55(2):122–32.PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Tavora F, Cresswell N, Li L, Ripple M, Fowler D, Burke A. Sudden coronary death caused by pathologic intimal thickening without atheromatous plaque formation. Cardiovasc Pathol. 2011;20(1):51–7.PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Ino Y, Kubo T, Tanaka A, Kuroi A, Tsujioka H, Ikejima H, Okouchi K, Kashiwagi M, Takarada S, Kitabata H, Tanimoto T, Komukai K, Ishibashi K, Kimura K, Hirata K, Mizukoshi M, Imanishi T, Akasaka T. Difference of culprit lesion morphologies between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study. JACC Cardiovasc Interv. 2011;4(1):76–82.PubMedCrossRefPubMedCentralGoogle Scholar
  19. 19.
    Niccoli G, Montone RA, Di Vito L, Gramegna M, Refaat H, Scalone G, Leone AM, Trani C, Burzotta F, Porto I, Aurigemma C, Prati F, Crea F. Plaque rupture and intact fibrous cap assessed by optical coherence tomography portend different outcomes in patients with acute coronary syndrome. Eur Heart J. 2015;36(22):1377–84.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Refaat H, Niccoli G, Gramegna M, Montone RA, Burzotta F, Leone AM, Trani C, Ammar AS, Elsherbiny IA, Scalone G, Prati F, Crea F. Optical coherence tomography features of angiographic complex and smooth lesions in acute coronary syndromes. Int J Cardiovasc Imaging. 2015;31(5):927–34.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Kwon JE, Lee WS, Mintz GS, Hong YJ, Lee SY, Kim KS, Hahn JY, Kumar KS, Won H, Hyeon SH, Shin SY, Lee KJ, Kim TH, Kim CJ, Kim SW. Multimodality intravascular imaging assessment of plaque erosion versus plaque rupture in patients with acute coronary syndrome. Korean Circ J. 2016;46(4):499–506.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Yonetsu T, Lee T, Murai T, Suzuki M, Matsumura A, Hashimoto Y, Kakuta T. Plaque morphologies and the clinical prognosis of acute coronary syndrome caused by lesions with intact fibrous cap diagnosed by optical coherence tomography. Int J Cardiol. 2016;203:766–74.PubMedCrossRefGoogle Scholar
  23. 23.
    Thondapu V. Non-newtonian blood flow simulation to improve detection of coronary atherosclerosis and its complications. University of Melbourne Faculty of Medicine, Dentistry and Health Sciences, Department of Mechanical Engineering; 2019.Google Scholar
  24. 24.
    Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.PubMedPubMedCentralCrossRefGoogle Scholar
  25. 25.
    Kolodgie FD, Burke AP, Farb A, Gold HK, Yuan J, Narula J, Finn AV, Virmani R. The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol. 2001;16:285–92.PubMedCrossRefGoogle Scholar
  26. 26.
    Finn AV, Nakano M, Narula J, Kolodgie FD, Virmani R. Concept of vulnerable/unstable plaque. Arterioscler Thromb Vasc Biol. 2010;30(7):1282–92.PubMedCrossRefGoogle Scholar
  27. 27.
    Calvert PA, Obaid DR, O’Sullivan M, Shapiro LM, McNab D, Densem CG, Schofield PM, Braganza D, Clarke SC, Ray KK, West NE, Bennett MR. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in vulnerable atherosclerosis) study. JACC Cardiovasc Imaging. 2011;4(8):894–901.PubMedCrossRefGoogle Scholar
  28. 28.
    Cheng JM, Garcia-Garcia HM, de Boer SP, Kardys I, Heo JH, Akkerhuis KM, Oemrawsingh RM, van Domburg RT, Ligthart J, Witberg KT, Regar E, Serruys PW, van Geuns RJ, Boersma E. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Eur Heart J. 2014;35(10):639–47.PubMedCrossRefGoogle Scholar
  29. 29.
    Stone GW, Maehara A, Lansky A, de Bruyne D, Cristea E, Mintz GS, Mehran R, McPherson J, Farhat N, Marso SP, Parise H, Templin B, White R, Zhang Z, Serruys PW. A prospective natural-history study of coronary atherosclerosis. NEJM. 2011;364:226–35.PubMedCrossRefGoogle Scholar
  30. 30.
    Roule V, Briet C, Lemaitre A, Ardouin P, Bignon M, Sabatier R, Blanchart K, Beygui F. Plaque erosion versus rupture characterization by optical frequency domain imaging before and after coronary stenting following successful fibrinolysis for ST-segment elevation myocardial infarction. Heart Vessel. 2019;34(3):401–9.CrossRefGoogle Scholar
  31. 31.
    Saia F, Komukai K, Capodanno D, Sirbu V, Musumeci G, Boccuzzi G, Tarantini G, Fineschi M, Tumminello G, Bernelli C, Niccoli G, Coccato M, Bordoni B, Bezerra H, Biondi-Zoccai G, Virmani R, Guagliumi G, Investigators O. Eroded versus ruptured plaques at the culprit site of STEMI: in vivo pathophysiological features and response to primary PCI. JACC Cardiovasc Imaging. 2015;8(5):566–75.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Hu S, Yonetsu T, Jia H, Karanasos A, Aguirre AD, Tian J, Abtahian F, Vergallo R, Soeda T, Lee H, McNulty I, Kato K, Yu B, Mizuno K, Toutouzas K, Stefanadis C, Jang IK. Residual thrombus pattern in patients with ST-segment elevation myocardial infarction caused by plaque erosion versus plaque rupture after successful fibrinolysis: an optical coherence tomography study. J Am Coll Cardiol. 2014;63(13):1336–8.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Thondapu V, Bourantas CV, Foin N, Jang I-K, Serruys PW, Barlis P. Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling. Eur Heart J. 2017;38:81–92.PubMedPubMedCentralGoogle Scholar
  34. 34.
    Gimbrone MA, Topper JN, Nagel T, Anderson KR, Garcia-Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000;902:230–40.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999;282:2035–42.PubMedCrossRefGoogle Scholar
  36. 36.
    Vergallo R, Papafaklis MI, D’Amario D, Michalis LK, Crea F, Porto I. Coronary plaque erosion developing in an area of high endothelial shear stress: insights from serial optical coherence tomography imaging. Coron Artery Dis. 2019;30(1):74–5.PubMedCrossRefGoogle Scholar
  37. 37.
    Yamamoto E, Thondapu V, Poon E, Sugiyama T, Fracassi F, Dijkstra J, Lee H, Ooi A, Barlis P, Jang IK. Endothelial shear stress and plaque erosion: a computational fluid dynamics and optical coherence tomography study. JACC Cardiovasc Imaging. 2019;12(2):374–5.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Niccoli G, Montone RA, Cataneo L, Cosentino N, Gramegna M, Refaat H, Porto I, Burzotta F, Trani C, Leone AM, Severino A, Crea F. Morphological-biohumoral correlations in acute coronary syndromes: pathogenetic implications. Int J Cardiol. 2014;171(3):463–6.PubMedCrossRefGoogle Scholar
  39. 39.
    Ferrante G, Nakano M, Prati F, Niccoli G, Mallus MT, Ramazzotti V, Montone RA, Kolodgie FD, Virmani R, Crea F. High levels of systemic myeloperoxidase are associated with coronary plaque erosion in patients with acute coronary syndromes: a clinicopathological study. Circulation. 2010;122(24):2505–13.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Mullick AE, Soldau K, Kiosses WB, Bell TA 3rd, Tobias PS, Curtiss LK. Increased endothelial expression of toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med. 2008;205(2):373–83.PubMedPubMedCentralCrossRefGoogle Scholar
  41. 41.
    Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow perturbation mediates neutrophil recruitment and potentiates endothelial injury via TLR2 in mice: implications for superficial erosion. Circ Res. 2017;121(1):31–42.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    Quillard T, Araujo HA, Franck G, Shvartz E, Sukhova G, Libby P. TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion. Eur Heart J. 2015;36(22):1394–404.PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Quillard T, Franck G, Mawson T, Folco E, Libby P. Mechanisms of erosion of atherosclerotic plaques. Curr Opin Lipidol. 2017;28(5):434–41.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Giannotta M, Trani M, Dejana E. VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity. Dev Cell. 2013;26(5):441–54.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel JB, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. Roles of PAD4 and NETosis in experimental atherosclerosis and arterial injury: implications for superficial erosion. Circ Res. 2018;123(1):33–42.PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    Pedicino D, Vinci R, Giglio AF, Pisano E, Porto I, Vergallo R, Russo G, Ruggio A, D’Aiello A, Flego D, Annibali G, Trotta F, Piacentini R, Niccoli G, Liuzzo G, Crea F. Alterations of hyaluronan metabolism in acute coronary syndrome: implications for plaque erosion. J Am Coll Cardiol. 2018;72(13):1490–503.PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Dai J, Xing L, Jia H, Zhu Y, Zhang S, Hu S, Lin L, Ma L, Liu H, Xu M, Ren X, Yu H, Li L, Zou Y, Zhang S, Mintz GS, Hou J, Yu B. In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study. Eur Heart J. 2018;39(22):2077–85.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Ozaki Y, Okumura M, Ismail TF, Motoyama S, Naruse H, Hattori K, Kawai H, Sarai M, Takagi Y, Ishii J, Anno H, Virmani R, Serruys PW, Narula J. Coronary CT angiographic characteristics of culprit lesions in acute coronary syndromes not related to plaque rupture as defined by optical coherence tomography and angioscopy. Eur Heart J. 2011;32(22):2814–23.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Bogale N, Lempereur M, Sheikh I, Wood D, Saw J, Fung A. Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI. Cardiovasc Revasc Med. 2016;17(2):113–8.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Kusama I, Hibi K, Kosuge M, Nozawa N, Ozaki H, Yano H, Sumita S, Tsukahara K, Okuda J, Ebina T, Umemura S, Kimura K. Impact of plaque rupture on infarct size in ST-segment elevation anterior acute myocardial infarction. J Am Coll Cardiol. 2007;50(13):1230–7.PubMedCrossRefGoogle Scholar
  51. 51.
    Kubo T, Imanishi T, Takarada S, Kuroi A, Ueno S, Yamano T, Tanimoto T, Matsuo Y, Masho T, Kitabata H, Tsuda K, Tomobuchi Y, Akasaka T. Assessment of culprit lesion morphology in acute myocardial infarction. J Am Coll Cardiol. 2007;50(10):933–9.PubMedPubMedCentralCrossRefGoogle Scholar
  52. 52.
    Lee CW, Hwang I, Park CS, Lee H, Park DW, Kang SJ, Lee SW, Kim YH, Park SW, Park SJ. Differences in intravascular ultrasound and histological findings in culprit coronary plaques between ST-segment elevation myocardial infarction and stable angina. J Thromb Thrombolysis. 2014;37(4):443–9.PubMedCrossRefGoogle Scholar
  53. 53.
    Higuma T, Soeda T, Abe N, Yamada M, Yokoyama H, Shibutani S, Vergallo R, Minami Y, Ong DS, Lee H, Okumura K, Jang I-K. A combined optical coherence tomography and intravascular ultrasound study on plaque rupture, plaque erosion, and calcified nodule in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol Intv. 2015;8(9):1166–76.CrossRefGoogle Scholar
  54. 54.
    Wang L, Parodi G, Maehara A, Valenti R, Migliorini A, Vergara R, Carrabba N, Mintz GS, Antoniucci D. Variable underlying morphology of culprit plaques associated with ST-elevation myocardial infarction: an optical coherence tomography analysis from the SMART trial. Eur Heart J Cardiovasc Imaging. 2015;16(12):1381–9.PubMedCrossRefGoogle Scholar
  55. 55.
    Kajander OA, Pinilla-Echeverri N, Jolly SS, Bhindi R, Huhtala H, Niemela K, Fung A, Vijayaraghavan R, Alexopoulos D, Sheth T. Culprit plaque morphology in STEMI - an optical coherence tomography study: insights from the TOTAL-OCT substudy. EuroIntervention. 2016;12(6):716–23.PubMedCrossRefGoogle Scholar
  56. 56.
    Ong DS, Lee JS, Soeda T, Higuma T, Minami Y, Wang Z, Lee H, Yokoyama H, Yokota T, Okumura K, Jang IK. Coronary calcification and plaque vulnerability: an optical coherence tomographic study. Circ Cardiovasc Imaging. 2016;9(1):e003929.PubMedCrossRefGoogle Scholar
  57. 57.
    Libby P, Pasterkamp G. Requiem for the ‘vulnerable plaque’. Eur Heart J. 2015;36(43):2984–7.PubMedGoogle Scholar
  58. 58.
    Hu S, Wang C, Zhe C, Zhu Y, Yonetsu T, Jia H, Hou J, Zhang S, Jang IK, Yu B. Plaque erosion delays vascular healing after drug eluting stent implantation in patients with acute coronary syndrome: an in vivo optical coherence tomography study. Catheter Cardiovasc Interv. 2017;89(S1):592–600.PubMedCrossRefGoogle Scholar
  59. 59.
    Hu S, Zhu Y, Zhang Y, Dai J, Li L, Dauerman H, Soeda T, Wang Z, Lee H, Wang C, Zhe C, Wang Y, Zheng G, Zhang S, Jia H, Yu B, Jang IK. Management and outcome of patients with acute coronary syndrome caused by plaque rupture versus plaque erosion: an intravascular optical coherence tomography study. J Am Heart Assoc. 2017;6(3):e004730.PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Prati F, Uemura S, Souteyrand G, Virmani R, Motreff P, Di Vito L, Biondi-Zoccai G, Halperin J, Fuster V, Ozaki Y, Narula J. OCT-based diagnosis and management of STEMI associated with intact fibrous cap. JACC Cardiovasc Imaging. 2013;6(3):283–7.PubMedPubMedCentralCrossRefGoogle Scholar
  61. 61.
    Jia H, Dai J, Hou J, Xing L, Ma L, Liu H, Xu M, Yao Y, Hu S, Yamamoto E, Lee H, Zhang S, Yu B, Jang IK. Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study). Eur Heart J. 2017;38(11):792–800.PubMedPubMedCentralGoogle Scholar
  62. 62.
    Puricel S, Arroyo D, Corpataux N, Baeriswyl G, Lehmann S, Kallinikou Z, Muller O, Allard L, Stauffer JC, Togni M, Goy JJ, Cook S. Comparison of everolimus- and biolimus-eluting coronary stents with everolimus-eluting bioresorbable vascular scaffolds. J Am Coll Cardiol. 2015;65(8):791–801.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Smits PC, Hofma S, Togni M, Vázquez N, Valdés M, Voudris V, Slagboom T, Goy J-J, Vuillomenet A, Serra A, Nouche RT, den Heijer P, van der Ent M. Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial. Lancet. 2013;381(9867):651–60.PubMedCrossRefPubMedCentralGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of CardiologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Division of Cardiovascular Medicine, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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