A 49-Year-Old Man with Limb Weakness and Painful Skin Lesions

  • Kara StavrosEmail author
  • Rajeev Motiwala
  • Lan Zhou
  • Susan C. Shin


Calciphylaxis is a rare and devastating condition that typically affects patients with chronic renal failure on dialysis. Painful skin lesions are often the hallmark of the disorder, although it can systemically affect any organ system including muscle. Skeletal muscle involvement from calciphylaxis often causes a painful myopathy due to muscle ischemia. A high index of clinical suspicion is needed to make an early and accurate diagnosis. Although skin biopsy is often diagnostic, advanced tissue necrosis may mask the underlying pathology. Muscle biopsy can be useful in such cases where myopathy is a clinical feature.


Calciphylaxis Myopathy Renal failure 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Kara Stavros
    • 1
    Email author
  • Rajeev Motiwala
    • 2
  • Lan Zhou
    • 3
  • Susan C. Shin
    • 4
  1. 1.Department of NeurologyWarren Alpert Medical School of Brown University, Rhode Island HospitalProvidenceUSA
  2. 2.Department of NeurologyNew York UniversityNew YorkUSA
  3. 3.Departments of Neurology and PathologyBoston University Medical CenterBostonUSA
  4. 4.Department of NeurologyIcahn School of Medicine at Mount SinaiNew YorkUSA

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