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Heartbeat and Respiration: Toward a Functional Chronobiology

  • Branko Furst
Chapter

Abstract

The search for the underlying lawfulness between respiration and heart rate variability has a long history and continues to be at the center of scientific inquiry. Because respiration is partially under conscious control, quantification of its effect on HR presents significant methodological limitations. The discovery of non-equilibrium processes in medicine and biology paved the way toward an expanded view of homeostasis based on nonlinear dynamics. Pulse and respiration are examples of a periodic, nonlinear behavior, exhibiting phase and frequency synchronization at whole number ratios, best demonstrated during periods of rest and the regenerative phase of sleep. The combined concepts of open systems and self-organization offer the possibility of understanding the organism as a spatial structure with life processes, i.e., nourishment, breathing, circulation, growth, regeneration, reproduction, and sense perception, proceeding in time. Life processes are closely linked to external (macrocosmic) rhythms in plants but become entrained and/or internalized in animals and humans. Their synchronization enables the emergence of a higher-level organization that is far-from-thermodynamic equilibrium. The spectrum of human biological rhythms spans several orders of magnitude, from high frequencies in the nervous system to intermediate, as extant in pulse and respiration, and to low-range frequencies in the metabolic system. The cardiovascular system entrains macrocosmic (external) and microcosmic (internal) rhythms by means of transcriptional and non-transcriptional metabolic clocks which persist even in explanted heart preparations and in stored blood. A functional division of the time organism into informational, rhythmical, and metabolic parts provides the bridge between the somatic and psychological functions on the one hand, and between the outer (macrocosmic) and inner (microcosmic) environments on the other. While metabolic processes that provide energy and sustain the function of the entire organism exhibit inherent anabolic/catabolic rhythms, reflected in fluctuations of core body temperature, the brain-bound consciousness is a catabolic process linked to the day/night cycle.

Keywords

Heart rate variability Respiratory sinus arrhythmia Chronocardiagram Synchrony of pulse and respiration Open systems Self-organization Dissipative structures Cardiorespiratory phase synchronization Thermodynamic equilibrium Active fluids Time organization Time structures Biological rhythms Microcosmic and macrocosmic rhythms Cardiovascular circadian clocks Spiral waves Linear time Cyclical time Threefold time organism Core body temperature Sleep–wakefulness cycle 

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Authors and Affiliations

  • Branko Furst
    • 1
  1. 1.Professor of AnesthesiologyAlbany Medical CollegeAlbanyUSA

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