IgG Glycans as a Biomarker of Biological Age

  • M. Vilaj
  • I. Gudelj
  • I. Trbojević-Akmačić
  • G. Lauc
  • M. PezerEmail author
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)


Immunoglobulin G (IgG) has an important role in various processes of the immune response and its functions can be modulated by N-glycans attached to its Fab and Fc portions. The composition of IgG glycans can be deciphered using different analytical methods, based on liquid chromatography, mass spectrometry and capillary electrophoresis. IgG glycome composition is partly heritable, but is also under the influence of various environmental factors. It therefore represents an interface between genes and environment, as evidenced by IgG glycosylation pattern changes associated with chronological age, various diseases and lifestyle-related variables. IgG glycans are therefore considered an excellent biomarker of the general health state of a person, i.e. biological age.


IgG glycome Aging Diseases Biological age Biomarker Inflammaging 



Antibody-dependent cellular cytotoxicity


Capillary gel electrophoresis with laser induced fluorescence detection


Constant heavy domain


Constant light domain


Fragment antigen binding


Fragment crystallizable


Fcγ receptor


Immunoglobulin G


Intravenous immunoglobulin


Liquid chromatography electrospray ionization mass spectrometry


Matrix assisted laser desorption/ionization time-of-flight mass spectrometry


Rheumatoid arthritis


Total plasma N-glycome


Ultra-high-performance liquid chromatography with fluorescence detection


Variable light domain


Variable heavy domain


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • M. Vilaj
    • 1
  • I. Gudelj
    • 1
  • I. Trbojević-Akmačić
    • 1
  • G. Lauc
    • 1
    • 2
  • M. Pezer
    • 1
    Email author
  1. 1.Genos Glycoscience Research LaboratoryZagrebCroatia
  2. 2.Faculty of Pharmacy and BiochemistryUniversity of ZagrebZagrebCroatia

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