Molecular Signature of Aging Driven by Wnt Signaling Pathway: Lessons from Nematodes

  • Marco Lezzerini
  • Yelena V. BudovskayaEmail author
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)


Aging is a universal biological process that afflicts every creature on this planet. To date, we have an inferior understanding of what causes this degeneration. A commonly held view is that aging is the result of damage accumulation over a lifetime. However, research has shown that aging is not only the result of wear and tear in the organism but also of genetic programs involved in organismal development that go awry as selective pressure is released. With this in mind, we have investigated the Wnt signaling pathway, as a significant and highly conserved developmental pathway that guides many essential events during embryonic and larval development. We also discuss how these genetic programs orchestrate changes in the organism that could cause aging and open a new research direction on the role of Wnt signaling in aging and age-related diseases.


Aging Wnt signaling Antagonistic pleiotropy Caenorhabditis elegans Developmental programs GATA transcriptional circuit Gene expression RNA sequencing Reproduction Metabolism 


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Authors and Affiliations

  1. 1.Laboratory Genetic Metabolic DiseasesAmsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and MetabolismAmsterdamThe Netherlands
  2. 2.TruMe IncSouth San FranciscoUSA

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