Circulating Biomarkers of Aging

  • Hongxia Zhang
  • Brian Wang
  • Kunlin JinEmail author
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)


A major goal of geroscience is to achieve the ability to predict the rate of aging using biomarkers for the purpose of extending lifespan and healthspan. Chronological aging is not a suitable marker as it does not capture the true status of age-related changes. So far, there is no biomarker or combination of biomarkers that has emerged even though some have shown promise. In this chapter, we summarize novel cellular, protein, and DNA-related biomarkers for biological aging that can be found specifically in the circulation “for the life of every living thing is in the blood”.


Aging Biomarkers Blood Lifespan Circulation MiRNA Protein Extracellular vesicles 



Alzheimer’s disease


Amyloid precursor protein


Apparent methylomic aging rate


Ascorbate free radical


Β2 microglobulin


Biomarker of aging


Blood-brain barrier


Caloric restriction


Central nervous system


Cerebrospinal fluid


Coronary artery disease

DNA methylation



Docosahexaenoic acid


Endothelial cells


Extracellular vesicles


Fibroblast growth factor receptor


Growth differentiation factor


Indoleamine 2,3-dioxygenase enzyme


Leukocyte telomere length


Oligodendrocyte progenitor cells


Peripheral blood mononuclear cells


Reactive oxygen species


Red blood cells


Relative leukocyte telomere length


Relative telomere length


Serum amyloid A


Sortilin related receptor 1


Superoxide dismutase


Telomere length


Vascular cell adhesion molecule 1


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pharmacology and NeuroscienceUniversity of North Texas Health Science CenterFort WorthUSA
  2. 2.Department of NeurologyNational Neuroscience InstituteSingaporeSingapore
  3. 3.Department of Pharmacology and NeuroscienceUniversity of North Texas Health Science Center at Fort WorthTXUSA

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