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Arterial Aging: The Role of Hormonal and Metabolic Status and Telomere Biology

  • Irina D. StrazheskoEmail author
  • Daria A. Kashtanova
  • Ekaterina N. Dudinskaya
  • Olga N. Tkacheva
Chapter
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)

Abstract

Age-associated arterial wall changes create an enzymatically and metabolically favorable environment for cardiovascular diseases development. Understanding the essence of the processes underlying the development of CVD can open up new opportunities for more effective preventive actions. Age, gender, blood pressure, lipid levels, type 2 diabetes mellitus are traditional cardiovascular risk factors used in the most popular models, such as Framingham and SCORE. However, these risk stratification systems have a number of limitations and explain no more than 50% reduction in mortality from cardiovascular diseases. There is not enough information on the association between signs of arterial wall aging and factors that determine the aging processes in general and in their interaction with cardiovascular risk factors. The aim of the work was to study the relationship between parameters of arterial wall aging, traditional risk factors, hormonal status, leukocyte telomere length. A total of 303 ambulatory participants (104 males and 199 females) were recruited. The subjects ranged between 23 and 91 years of age, with a mean age of 51.8 ± 13.3 years. Based on the results obtained, the following conclusions can be drawn: the value of traditional cardiovascular risk factors for the vascular wall changes is reduced in older age; carbohydrate metabolism disorders and hypertension are “universal” risk factors most closely associated with the arterial wall condition in both younger and older group. To predict changes in the vascular wall, it is advisable to study insulin resistance, growth hormone, insulin-like growth factor-1 activity and leukocyte telomere length along with conventional cardiovascular risk factors.

Keywords

Arterial aging Cardiovascular risk factors Insulin resistance Growth hormone Insulin-like growth factor-1 Leukocyte telomere length Telomerase activity 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Irina D. Strazhesko
    • 1
    Email author
  • Daria A. Kashtanova
    • 1
  • Ekaterina N. Dudinskaya
    • 1
  • Olga N. Tkacheva
    • 1
  1. 1.Russian Clinical Research Center for GerontologyPirogov Russian National Research Medical UniversityMoscowRussian Federation

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