Are There Reliable Biomarkers for Immunosenescence and Inflammaging?

  • Tamas FulopEmail author
  • Alan Cohen
  • Glenn Wong
  • Jacek M. Witkowski
  • Anis Larbi
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)


Aging is accompanied by changes in the immune system, culminating in immunosenescence on one hand and inflammaging on the other. Science is striving for biomarkers to capture these heterogenous complex processes. However, when the basic interpretation does not capture correctly the underlying phenomenon, the biomarkers may not be accurate either. Thus, we tried to give a new interpretation of the immune changes with aging as mostly adaptative (and even partially beneficial) in physiological circumstances. So we need new biomarkers which could capture these novel concepts this new reality concomitantly to the old ones. Finding and applying them would in our opinion result in a better modulation of the immune changes in elderly subjects.


Inflammaging Age related diseases Innate immune system Adaptive immune system Trained innate immunity Biomarkers Immunadaptation 



This work was supported by grants from Canadian Institutes of Health Research (CIHR) (No. 106634), the Société des médecins de l’Université de Sherbrooke and the Research Center on Aging of the CIUSSS-CHUS, Sherbrooke, by the Polish Ministry of Science and Higher Education statutory grant 02-0058/07/262 to JMW and by Agency for Science Technology and Research (A*STAR JCO 1434m00115 and SRIS SIG18026) to AL.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tamas Fulop
    • 1
    Email author
  • Alan Cohen
    • 2
  • Glenn Wong
    • 3
  • Jacek M. Witkowski
    • 4
  • Anis Larbi
    • 3
    • 5
  1. 1.Research Center on Aging, Graduate Program in Immunology, Faculty of Medicine and Health Sciences, Department of MedicineUniversity of SherbrookeSherbrookeCanada
  2. 2.Research Center on Aging, Faculty of Medicine and Health Sciences, Department of Family MedicineUniversity of SherbrookeSherbrookeCanada
  3. 3.Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)SingaporeSingapore
  4. 4.Department of PathophysiologyMedical University of GdanskGdanskPoland
  5. 5.Department of Biology, Faculty of ScienceUniversity Tunis El ManarTunisTunisia

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