DNA Methylation Markers to Assess Biological Age
Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for development of the clocks.
KeywordsDNA methylation Biomarker of aging Epigenetic clocks Elastic net regression
Supported by NIH grants.
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