DNA Methylation Markers to Assess Biological Age

  • Dmitriy I. PodolskiyEmail author
  • Vadim N. Gladyshev
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)


Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for development of the clocks.


DNA methylation Biomarker of aging Epigenetic clocks Elastic net regression 



Supported by NIH grants.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Genetics, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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