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Genetic Markers of Extreme Human Longevity

  • Paola SebastianiEmail author
  • Anastasia Gurinovich
  • Harold Bae
  • Thomas T. Perls
Chapter
Part of the Healthy Ageing and Longevity book series (HAL, volume 10)

Abstract

We review issues related to studying the genetics of extreme human longevity, including the definition of the phenotype, the choice of appropriate controls, the effect of population structure and assortative mating. We then discuss the important contributions to the genetics of extreme human longevity of the last few years that have arisen from genome-wide association studies and the work that is needed to discover additional longevity genes.

Keywords

APOE Assortative mating Centenarians FOXO3 Genetic variants Genome-wide principal components Meta-analysis Sequencing 

Notes

Funding

This work was supported by the National Institute on Aging (U19AG023122, R21AG056630 and R01AG061844).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Paola Sebastiani
    • 1
    Email author
  • Anastasia Gurinovich
    • 1
  • Harold Bae
    • 2
  • Thomas T. Perls
    • 3
  1. 1.Department of BiostatisticsBoston University School of Public HealthBostonUSA
  2. 2.College of Public Health and Human SciencesOregon State UniversityCorvallisUSA
  3. 3.Department of Medicine, GeriatricBoston University School of Medicine and Boston Medical CenterBostonUSA

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