While some applications, such as social networking, were born in the Cloud and are natural fits, many other traditional products such as CRM (customer relationships management) were adapted by Salesforce.com and now are flourishing in the Cloud. Main attraction for migrating or creating applications in the cloud is the economy of scale with pay as you need model for usage of IT resources. For customers, it translates to competitive products and cheaper services. Cloud Computing has ushered in a new era and proverbial gold rush of opportunities. There are three types of online business models of interactions between businesses (B) and their customers (C), namely, B2C, B2B, and C2C. Several real-life examples are narrated of companies that have thrived only due to Internet and Cloud computing in their business models. Another set of three case studies, using IoT devices in a cloud, multi-party Cloud, and software-based hardware security modules, wrap up this chapter.