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MR Plaque Imaging in Peripheral Artery Disease

  • Jie Sun
  • Chun YuanEmail author
Chapter

Abstract

Lower extremity peripheral artery disease (PAD) is one of the most common local manifestations of systemic atherosclerosis. In population studies conducted in the United States and Europe, PAD is estimated to affect approximately 7% of those aged ≥40 years and 21% of those aged ≥65 years. Globally, more than 200 million people are living with PAD, and the number is expected to continue to grow in the next decade due to aging populations worldwide and the increasing prevalence of chronic kidney disease and diabetes. The majority of PAD patients either have no apparent symptoms or have atypical symptoms due to individual variations in lifestyle, pain threshold, or comorbidities. Given the lack of effective medical therapies for PAD beyond exercise programs, understanding and prevention of disease progression at the subclinical stage represent an important question as prophylactic measures are likely most effective in the early stage of PAD.

Keywords

MR plaque imaging Peripheral artery disease Lower extremity peripheral artery disease PAD 

Abbreviations

ABI

Ankle-brachial index

DANTE

Delay alternating with mutation for tailored excitation

DESS

Double-echo steady-state

DIR

Double inversion recovery

FLASH

Fast low-angle shot

FSE

Fast spin echo

IPH

Intraplaque hemorrhage

MERGE

Motion-sensitized driven-equilibrium prepared rapid gradient echo

MPRAGE

Magnetization-prepared rapid acquisition gradient echo

MSDE

Motion-sensitized driven-equilibrium

PAD

Peripheral artery disease

SFA

Superficial femoral artery

SPACE

Sampling perfection with application-optimized contrasts using different flip angle evolution

WALCS

Walking and Leg Circulation Study

Notes

Disclosures

Dr. Sun receives grant support from the American Heart Association (17MCPRP33671077). Dr. Yuan receives grant support from the National Institutes of Health (R01 HL103609 and R01 NS092207) and serves as a member of Philips Radiology Advisory Network.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of WashingtonSeattleUSA
  2. 2.University of WashingtonSeattleUSA

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