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Liver Inflammation: Short Uptodate

  • Mariana Mihaila
  • Ecaterina Bontas
  • Cecilia Patru
Chapter

Abstract

Without a doubt, the inflammation is a key process in liver pathology. At the same time, it represents the liver response to different and constant types of aggressions such as viral infections, alcohol, and drug-toxicity. According to current evidence, the liver inflammation activates immune cells such as Kupffer cells, innate macrophages, monocytes, natural killer cells, neutrophils and other granulocytes, and dendritic cells. All of them contribute to liver inflammation. Herein, we try to underline the basic knowledge of human liver inflammation.

Keywords

Inflammation Liver inflammation Immune innate cells Metaflammation Steatosis Steatohepatitis 

Abbreviations

ALD

Alcoholic liver disease

DCs

Dendritic cells

HMGB1

Protein (high-mobility group box-1) or HMG-1 (high—mobility group)1

IL

Interleukin

NAFLD

Nonalcoholic fatty liver disease

NASH

Non-alcoholic steatohepatitis

PAMPs

Pathogen Associated Molecular Patterns

PRRs

The pathogen recognition receptors

TNF

Tumor necrosis factor

Notes

Conflicts of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mariana Mihaila
    • 1
  • Ecaterina Bontas
    • 2
  • Cecilia Patru
    • 3
  1. 1.Fundeni Clinical InstituteBucureștiRomania
  2. 2.“Prof. C.C. Iliescu” Emergency Institute for Cardiovascular DiseasesBucharestRomania
  3. 3.“Carol Davila” Central Military Emergency University HospitalBucharestRomania

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