Role of HSP70 in Plasticity and Memory

  • Rossana Rosa Porto
  • Lucas de Oliveira Alvares
Part of the Heat Shock Proteins book series (HESP, volume 20)


HSP70 are molecular chaperones that are present in neuronal cells, acting in cytoprotection and thermotolerance, preventing inflammation, apoptosis and cell death. It can be induced by a variety of stressful insults, but also by synaptic activity. Many physiological stimuli that induce long-term potentiation are also capable of stimulating the synthesis of HSP70. It’s induction is enhanced in the hippocampus after learning, during memory consolidation window, which is correlated to the animal performance and not the stress induced by the task. It is also induced markedly surround the synapses between the Shaffer collateral and pyramidal cells of the hippocampal CA1 region, a crucial structure involved in associative learning. Infusion of exogenous HSP70 facilitates memory consolidation through modulation of MAPK family activity in the hippocampus. HSP70 has been shown to be important in memory-related processes and can be quickly induced after training, indicating that memory is being mastered. Thus, it may be considered useful to be used as a learning index and also has a great potential as a pharmacological target to treat memory impairments. This chapter briefly reviews recent advances in our understanding of the role of HSP70 in synaptic plasticity and memory consolidation.


Alzheimer’s disease Fear conditioning LTP MAPK Memory consolidation Synaptic plasticity 





Alzheimer’s disease


α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid


brain-derived neurotrophic factor


calcium and calmodulin dependent protein kinase IV


calcium and calmodulin dependent protein kinase II


cyclic adenosine monophosphate


context fear conditioning


cystic fibrosis transmembrane conductance regulator


central nervous system


cAMP responsive element


extracellular signal regulated kinase


glutamate receptor


heat hock factor


heat shock proteins


c-Jun NH (2) -terminal kinase


long-term depression


Long-term potentiation


mitogen-activated protein kinase


nuclear factor κappa B


neuronal growth factor


N-methyl D-aspartate


phosphorylated extracellular signal regulated kinase


c-Jun NH (2) -terminal phosphorylated kinase


protein kinase A


protein kinase B


protein kinase C


post-traumatic stress disorder


recombinant 70 kDa heat shock protein


N-ethylmaleimide soluble factor receptor binding protein


serum response element


toll like receptor



The authors thank the Neuroscience Post-Graduate Program from the Federal University of Rio Grande do Sul (UFRGS). This work was supported in part by CAPES and PROPESQ (UFRGS).


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rossana Rosa Porto
    • 1
  • Lucas de Oliveira Alvares
    • 1
  1. 1.Neurobiology of Memory Laboratory, Biophysics Department, Biosciences InstituteFederal University of Rio Grande do SulPorto AlegreBrazil

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