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Role of HSP70 in Plasticity and Memory

  • Rossana Rosa Porto
  • Lucas de Oliveira Alvares
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 20)

Abstract

HSP70 are molecular chaperones that are present in neuronal cells, acting in cytoprotection and thermotolerance, preventing inflammation, apoptosis and cell death. It can be induced by a variety of stressful insults, but also by synaptic activity. Many physiological stimuli that induce long-term potentiation are also capable of stimulating the synthesis of HSP70. It’s induction is enhanced in the hippocampus after learning, during memory consolidation window, which is correlated to the animal performance and not the stress induced by the task. It is also induced markedly surround the synapses between the Shaffer collateral and pyramidal cells of the hippocampal CA1 region, a crucial structure involved in associative learning. Infusion of exogenous HSP70 facilitates memory consolidation through modulation of MAPK family activity in the hippocampus. HSP70 has been shown to be important in memory-related processes and can be quickly induced after training, indicating that memory is being mastered. Thus, it may be considered useful to be used as a learning index and also has a great potential as a pharmacological target to treat memory impairments. This chapter briefly reviews recent advances in our understanding of the role of HSP70 in synaptic plasticity and memory consolidation.

Keywords

Alzheimer’s disease Fear conditioning LTP MAPK Memory consolidation Synaptic plasticity 

Abbreviations

17-AAG

17-N-allylamino-17-deethoxyglydanamycin

AD

Alzheimer’s disease

AMPA

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

BDNF

brain-derived neurotrophic factor

CAMKIV

calcium and calmodulin dependent protein kinase IV

CAMKII

calcium and calmodulin dependent protein kinase II

cAMP

cyclic adenosine monophosphate

CFC

context fear conditioning

CFTR

cystic fibrosis transmembrane conductance regulator

CNS

central nervous system

CRE

cAMP responsive element

ERK

extracellular signal regulated kinase

GluR

glutamate receptor

HSF

heat hock factor

HSP

heat shock proteins

JNK

c-Jun NH (2) -terminal kinase

LTD

long-term depression

LTP

Long-term potentiation

MAPK

mitogen-activated protein kinase

NF-κB

nuclear factor κappa B

NGF

neuronal growth factor

NMDA

N-methyl D-aspartate

p-ERK

phosphorylated extracellular signal regulated kinase

p-JNK

c-Jun NH (2) -terminal phosphorylated kinase

PKA

protein kinase A

PKB

protein kinase B

PKC

protein kinase C

PTSD

post-traumatic stress disorder

rHSP70

recombinant 70 kDa heat shock protein

SNARE

N-ethylmaleimide soluble factor receptor binding protein

SRE

serum response element

TLR

toll like receptor

Notes

Acknowledgements

The authors thank the Neuroscience Post-Graduate Program from the Federal University of Rio Grande do Sul (UFRGS). This work was supported in part by CAPES and PROPESQ (UFRGS).

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rossana Rosa Porto
    • 1
  • Lucas de Oliveira Alvares
    • 1
  1. 1.Neurobiology of Memory Laboratory, Biophysics Department, Biosciences InstituteFederal University of Rio Grande do SulPorto AlegreBrazil

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