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Role of Heat Shock Proteins in Brain Tumors

  • George A. Alexiou
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 20)

Abstract

Heat shock proteins (HSP) constitute a major focus of cancer research. HSP have been found to be elevated in many human cancers and their expression has been related to patients’ prognosis. GBM is the most common primary malignant brain tumor with dismal prognosis. HSP have attracted a major interest as important anti-cancer targets since they have been implicated in glioma growth, invasion, angiogenesis and resistance to treatment. HSP inhibitors and vaccines are currently tested as new agents for brain tumors treatment.

Keywords

Brain tumor Glioma Heat shock proteins Inhibitors Medulloblastoma Vaccines 

Abbreviations

GBM

Glioblastoma

HIF-1

Hypoxia-inducible factor-1

Hsp

Heat shock protein

HSPPC-96

Heat shock protein-peptide complex-96

TMZ

Temozolomide

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • George A. Alexiou
    • 1
  1. 1.Department of Neurosurgery, School of MedicineUniversity of IoanninaIoanninaGreece

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