Endothelial Function in Normal and Diseased Vessels

  • Mridul Rana
  • Zarius Ferozepurwalla
  • Justin MasonEmail author
Part of the Learning Materials in Biosciences book series (LMB)


This chapter provides a comprehensive overview of the endothelium, its physiology and its dysfunction. We will begin by exploring the origin of endothelial cells and their importance in the regulation of blood pressure, inflammation and vascular homeostasis. From there, leukocyte transmigration will be expanded upon, with a discussion on relevant novel research. Next, the interplay of haemodynamic factors, namely differential flow patterns, on the endothelium will be explored, including several key mechanosignalling facets. Finally, the role of nitric oxide and endothelin-1 in regulating vascular tone will be examined.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mridul Rana
    • 1
  • Zarius Ferozepurwalla
    • 1
  • Justin Mason
    • 2
    Email author
  1. 1.Imperial College LondonLondonUK
  2. 2.National Heart and Lung Institute, Vascular Sciences, Imperial College LondonLondonUK

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