Substrate Remodeling in Heart Failure

  • Angeliki Iakovou
  • Samuel Guymer
  • Rasheda ChowdhuryEmail author
Part of the Learning Materials in Biosciences book series (LMB)


With the fundamentals of heart failure already discussed, this chapter will explain three integral facets of the remodeling process: electrophysiological, fibrotic, and mitochondrial. Instigated by interacting networks of neurohormonal and chemical signaling, these systems collectively contribute to much of the longitudinal functional decline observed, as well as significantly heightening the risk of sudden cardiac death. In addition to expanding upon their alteration in heart failure, this chapter will provide a brief overview of the fundamental pathway that underlies angiotensin-II-mediated fibrosis. Finally, novel pharmacological agents to combat these deleterious changes will be evaluated.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Angeliki Iakovou
    • 1
  • Samuel Guymer
    • 2
  • Rasheda Chowdhury
    • 3
    Email author
  1. 1.Queen Mary University of LondonLondonUK
  2. 2.Imperial College LondonLondonUK
  3. 3.National Heart and Lung Institute, Myocardial Function, Imperial College LondonLondonUK

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