Reducing mast cells number is a therapeutic approach in mastocytosis and other diseases in which mast cells number is increased. The number of mast cells may be reduced by the targeted induction of apoptosis or by blocking their recruitment, migration and differentiation.
- Pipkorn U, Hammarlund A, Enerbäck L (1989) Prolonged treatment with topical glucorticoids results in an inhibition of the allergen-induced weal-and-flare response and a reduction in skin mast cell numbers and histamine content. Clin Exp Allergy 19:19–25Google Scholar
- Pryer NK, Lee LB, Zadovaskaya R et al (2003) Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors. Clin Cancer Res 9:5729–5734Google Scholar
- Schneweiss MA, Peter Barbara, Blatt Katharina et al (2016) The multi-kinase inhibitor DCC-2618 inhibits proliferation and survival of neoplastic mast cells and other cell types involved in systemic mastocytosis. Blood 128:1965Google Scholar